内皮素-1在喉癌组织中的表达  

Expression of Endothelin-1 in laryngeal carcinoma

作　　者：张剑[1] 钟伟[1] 罗五根[1] 张志远[1] 

机构地区：[1]南昌大学第一附属医院耳鼻咽喉-头颈外科,南昌330006

出　　处：《临床耳鼻咽喉科杂志》2006年第24期1124-1125,共2页Journal of Clinical Otorhinolaryngology

摘　　要：目的:研究内皮素-1(ET-1)在喉癌组织中的表达及其意义。方法:采用免疫组织化学SP法检测30例喉癌组织、20例喉良性病变组织及10例喉正常黏膜中ET-1的表达,结合喉癌临床分期进行统计学分析。结果:ET-1在3种组织中的阳性表达均差异有统计学意义(均P<0.05),其中在喉癌组织中表达最高,喉正常组织中表达最低。ET-1在喉癌各临床分期标本中的表达均差异有统计学意义(均P<0.05),分期越晚,表达越高。结论:ET-1在喉癌中呈高表达,对喉癌的发生、发展可能发挥重要作用。Objective：To study the expression and clinical significance of Endothelin-1 in laryngeal carcinoma. Method：Immunohistochemical （SP） method was used to detect the expression of Endothelin-1 in 30 cases of laryngeal carcinoma,20 cases of laryngeal benign lesions and 10 cases of. The relationship between the expression of Endothelin 1 and the clinic stage was analysed by SPSS12.0 software. Result：The positive expression of Endothelin-1 in all three type tissues. There is a significant difference between the laryngeal carcinoma and the laryngeal benign lesions, the laryngeal carcinoma and the normal laryngeal mucous membrane, the laryngeal benign lesions and the normal laryngeal mucous membrane（ P 〈0.05）. The highest expression of Endothelin-1 is in laryngeal carcinoma tissue. In laryngeal carcinoma tissue, the advanced clinical stage, the more higher expression of endothelin- 1. ConcIusion：Positive expression of Endothelin -1 in laryngeal carcinoma tissue was highest in three tissue. It may be play an important role in carcinogenesis and progress of laryngeal carcinoma,

关 键 词：喉肿瘤 内皮素-1 

分 类 号：R739.65[医药卫生—肿瘤]