乳腺癌患者治疗前后血清CA153、SA、TNF-α检测的临床意义  

Clinical Significance of Measurement of Changes of Serum CA153,SA,TNF-α Contents After Treatment in Patients with Breast Cancer

作　　者：周军[1] 王昭昕[1] 汪瑞[1] 

机构地区：[1]江苏省连云港市第一人民医院普外科,222002

出　　处：《放射免疫学杂志》2006年第6期466-467,共2页Journal of Radioimmanology

摘　　要：目的探讨乳腺癌患者治疗前后血清糖类抗原CA153(CA153)、唾液酸(SA)和肿瘤坏死因子-α(TNF-α)含量。方法应用放射免疫分析和分光光度计法对32例乳腺癌患者进行了治疗前后血清CA153、SA、TNF-α含量检测。并以30名正常女性作比较。结果治疗前乳腺癌患者血清CA153、SA、TNF-α水平均非常显著地高于正常人组(P<0.01),治疗后6个月则与正常人比较无显著性差异(P>0.05)。结论乳腺癌患者血清CA153、SA、TNF-α含量的变化与该病的发生和发展密切相关。Objective To deteel the changes of serum CA153, SA, TNF -α contents both before and after treatment in patients with breast cancer. Methods Serum, contents of CA153, TNF -α （with RIA）, SA （with Spectraphotometry） were measured in 32 patients with breast cancer both belore and after treatment as well as in 30 controls. Results Before surgery, serum levels of CA153, SA and TNF -α in patients with breast cancer were significantly higher than those in the eontrols（ P 〈 0. 01 ）. Six months after surgery, these levels dropped markedly to approaching normality （P 〉 0. 05）. Conclusion The serum contents of CA 153, SA and TNF -α in patients with breast cancer were well related to tile development and progression of the discase process.

关 键 词：乳腺癌 糖类抗原153 唾液酸 肿瘤坏死因子-Α 

分 类 号：R737.9[医药卫生—肿瘤]