肝硬化患者血清IL-6、IL-10和HA、PⅢP检测的临床意义  

Clinical Significance of Determination of Changes of Serum IL-6,IL-10,HA and PⅢP Levels in Patients with Liver Cirrhosis

作　　者：吴友山[1] 秦继宝[1] 

机构地区：[1]江苏省连云港市东方医院消化科,222042

出　　处：《放射免疫学杂志》2006年第6期472-473,共2页Journal of Radioimmanology

摘　　要：目的探讨了肝硬化患者血清IL-6、IL-10和HA、PⅢP水平的变化及临床意义。方法分别应用放免法和ELISA法对61例肝硬化患者进行了血清IL-6、IL-10和HA、PⅢP含量检测并与30名正常人作比较。结果肝硬化患者血清IL-6、IL-10和HA、PⅢP含量均非常显著地高于正常人组(P<0.01),相关分析显示,肝硬化患者血清HA、PⅢP水平与IL-6、IL-10呈明显正相关(r=0.6216、0.5127、0.4875、0.4715,P<0.01)。结论细胞因子IL-6、IL-10在肝纤维化形成中发挥重要作用,在早期肝纤维化的诊断中具有一定的临床实用价值。Objective To investigate the cfinical significance of changes of serum IL-6、IL-10 HA and PⅢP levels in patients with liver cirrhosis. Methods Serum HA,PⅢP （with RIA） and IL -6, IL- 10 （with ELISA） levels were detected in 61 patients with liver cirrhosis and 30 controls. Results The serum IL-6、IL-10 HA and PⅢP levels in the patients were significantly higher Ihan those in controls （P 〈0. 01 ）. Serum HA, PⅢ P and IL-6, IL-10 were mutually positively correlated （r = 0. 6216,0. 5127, 0. 4875, P 〈 0.01 ）. Conclusion The cytokines IL -6 and IL - 10 played important role in the pathogeness of liver fibrosis and might be regarded as early indicator for diagnosis. Key Words

关 键 词：肝硬化 白细胞介素-6 白细胞介素-10 透明质酸 Ⅲ型胶原 

分 类 号：R575.2[医药卫生—消化系统]