癫癎患者抗癫癎治疗时脑电图和发作诱因与再发关系  

EEG findings and activated factors in association with seizure recurrence in children with epilepsy in treatment with antiepileptic drugs

作　　者：陶拓宇[1] 李乐加[1] 逯恒东[1] 卓娅[1] 

机构地区：[1]南京医科大学附属南京脑科医院视频脑电图室,江苏南京210029

出　　处：《临床神经电生理学杂志》2006年第6期353-355,共3页Journal of Clinical Electroneurophysiology

摘　　要：目的:探讨癫癎患者在药物治疗中脑电图、发作诱因与再发的关系,企为临床治疗提供参考指标。方法:分别对97例青少年癫癎患者行脑电图检查并追踪再发情况,比较脑电图、发作诱因与临床再发之间的关系。结果:97例患者中有49例脑电图正常,其中9例(18％)有癫癎再发,48例脑电图异常,其中38例(79％)有癫癎再发。此38例癫癎再发分别属于Ⅰ、Ⅱ、Ⅲ型异常脑电图,相应各有8、11、19例再发。脑电图正常而出现癫癎再发的9例中,有诱因者8例(89％),无诱因者1例(11％),脑电图异常而出现癫癎再发的38例中,有诱因者20例(53％),无诱因者18例(47％)。结论:青少年癫癎患者抗癫癎治疗时的脑电图表现与临床再发有相关性,其中有癎样放电者出现再发可能性最大。脑电图正常时出现再发常有诱因,而脑电图异常时出现再发常缺乏诱因。Objective： To study the association within EEG findings, activited factors and seizure recurrence in children with epilepsy during treatment with antiepileptic drugs. Methods; In 97 children with epilepsy treated by antiepileptic drugs, Video-EEGs were performed after the first seizure, both awake and asleep, and sphenidal EEGs for all patients. After EEG examinations, patients were followed by telephone interviews at least every 3 months to ascertain any seizure recurrence. EEG findings and risk factors were compared with seizure recurrence. Results： Forty nine of the 97 patients with epilepsy had normal EEGs, and the number of seizure recurrence was 9 in the 49 patients . Forty-eight of the 97 patients had abnormal EEG,and the number of seizure recurrence was 38 in the 48 patients . Of the 9 of 49 patients with normal EEG , 8 patients had risk factor and 1 patient had no risk factor. In the 38 patients with abnormal EEG, 20 patients had risk factors, 18 patients had no risk factor. Conclusions; EEG abnormalities in most seizures are associated with an increased risk of seizure recurrence on antiepileptic drugs treatment in children with an epilepsy, and patients with epileptiform EEG abnormalities have a higher seizure recurrence rate than that of patients with other EEG abnormalities. In children with epilepsy , normal EEGs, most seizure recurrence involve risk factors, and in children with epilepsy and abnormal EEGs , most seizures recurrence do not involve risk factors.

关 键 词：癫痫 脑电图 再发 抗癫痫药 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]