无抽搐电休克治疗对P300的影响  

Effects of modified electric convulsive therapy on P300

作　　者：钱卫娟[1] 范俭雄[1] 周群[1] 李乐加[1] 高晓宁[1] 

机构地区：[1]南京医科大学附属脑科医院精神科,210029

出　　处：《临床精神医学杂志》2006年第6期330-332,共3页Journal of Clinical Psychiatry

基　　金：南京医科大学科技发展基金资助项目(NY04043)

摘　　要：目的:评定无抽搐电休克治疗(MECT)对P300的影响。方法:对31例精神疾病患者分为单纯MECT组及MECT合并精神药物治疗组,在MECT前后进行P300检测。结果:17例单纯MECT组治疗后P3潜伏期显著缩短(P<0.05),P2波幅显著升高(P<0.05);14例MECT合并低剂量精神药物组治疗后靶刺激N1、P2、N2、P3潜伏期均显著缩短(P均<0.05),P3波幅显著升高(P<0.05);两组间在治疗前P300差异均无显著性(P均>0.05),但治疗后合并用药组N2、P3潜伏期缩短,P3波幅升高,较单纯MECT组差异显著(P<0.05)。结论:MECT对P300有一定改善,可能表示对认知功能无明显损害。Objective： To estimate the effects of modified electric convulsive therapy （MECT） on P300, Method： It was detected for P300 at pre and post-MECT in 31 patients with psychiatric disorders. Results： It was significantly shorter for P3 latency at posttreatment than pretreatment （ P 〈 0.05） and significantly higher for P2 amplitude at posttreatment （ P 〈 0.05） in 17 patients taking alone MECT; It was significantly shorter for target stimulation the latency of N1 ,P2, N2, P3 at posttreatment than pretreatment （all P 〈 0.05 ） and significantly higher for P3 amplitude at posttreatment （ P 〈 0.05） in 14 patients taking combination psychotropic drug at low dose with MECT; Before treatment it wasn＇t significantly difference bettween two groups （all P 〉 0.05 ）, but they were significantly shorter for the latency of N2 ,P3 and higher for the amplitude of P3 after treatment in group of taking combination psychotropic drug （ all P 〈 0.05）. Conclusion： MECT may somewhat improve P300. It possibly shows do not damage the cognitive of function significantly.

关 键 词：无抽搐电休克治疗 P300 认知功能 

分 类 号：R749.053[医药卫生—神经病学与精神病学]