7,3’,5’-三取代黄烷酮和黄酮醇类化合物的合成  

Synthesis of 7,3',5'-Trisubstituted Flavanones and Flavonols

作　　者：汪秋安[1] 方伟琴[1] 廖头根[2] 

机构地区：[1]湖南大学化学化工学院,湖南长沙410082 [2]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650204

出　　处：《湖南大学学报（自然科学版）》2006年第6期98-102,共5页Journal of Hunan University:Natural Sciences

基　　金：国家"十五"攻关项目(2001BA535C)

摘　　要：以3,5-二羟基苯甲酸和间苯二酚为原料,分别经酯化、乙酰化、甲氧甲氧基保护或甲基化、酰肼化、氧化、醛酮缩合、环化、Algar-Flynn-Oyamada反应以及脱保护基等步骤,以21%~32%的总收率合成了7,3’,5’-三取代黄烷酮1a^1b和黄酮醇类化合物2a^2b,所有合成产物通过1H NMR,IR,MS进行了结构确证.其中黄烷酮1b是从药用植物中间锦鸡儿Caragana intermedia Kang etH.C.Fu中分离得到的新天然有机化合物,此次为首次全合成.Flavanones la - lb and flavonols 2a - 2b were synthesized by esterification, acetylation, methoxymethyl protection or methylation, hydrazidation, oxidation, aldol condensation, cyclization, Algar-Flynn-Oyamada reaction and deprotection, using 3,5-dihydroxybenzoic acid and resorcinol as the materials in overall yield of 21%--32%. Their structures were confirmed by 1HNMR, IR and mass spectra. The compound 1b, a new natural flavanone in China isolated from the medicinal plant Caragana intermedia Kang et H. C. Fu, was firstly synthesized.

关 键 词：合成 黄烷酮 黄酮醇 7 3’ 5’-三羟基黄烷酮 

分 类 号：O624[理学—有机化学]