阿尔茨海默病与血浆同型半胱氨酸水平的相关性研究  

The relationship between Alzheimer disease and plasma homocysteine level

作　　者：张建平[1] 张新颜[1] 

机构地区：[1]商丘市第一人民医院神经内科,河南省商匠476100

出　　处：《中国基层医药》2006年第11期1834-1836,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨阿尔茨海默病(AD)与血浆同型半胱氨酸(HCY)水平的关系。方法68例AD患者测定血浆HCY、维生素B12、叶酸水平及简易精神状态量表(MMSE)评分等,并与60例健康老人作对照比较。结果AD组患者血浆HCY水平明显高于对照组,而维生素B12、叶酸水平明显低于对照组(均P<0．01);在AD组,当患者血浆HCY值>15μmol／L时,其AD的优势比OR值为4．3,95％CI为1．89～7．43;AD组和对照组血浆HCY水平与维生素B12、叶酸水平及MMSE评分均呈显著负相关性。结论血浆HCY水平升高是AD重要的危险因素,体内缺乏维生素B12、叶酸等营养元素是导致血浆HCY升高的原因。Objective To investigate the relationship between Alzheimer disease（AD） and plasma homocysteine（HCY） level. Methods Rate of mini mental state examination（MMSE） and levels of plasma homocysteine and folate and vitamin B12 were determined in 68 AD patients, which were compared with 60 healthy older. Results The mean plasma level of HCY was higher in AD patients than that in contrast group, and the very reverse of plasma level of folate and vitamin B12 （ P 〈 0.01 ）. In AD group, when HCY 〉 15μmol/L, the odd ratio（OR） was 4.3 （95 % CI1.89-7.43 ）. Plasma level of HCY was negatively correlated with that of folate and vitamin B12 and rate of MMSE in two groups. Conclusion The high level of plasma HCY is an important risky factor to AD patients. The lack of nutrition elements of folate and vitamin B12 et al can result in the rising of plasma HCY.

关 键 词：半胱氨酸 维生素B12 叶酸 阿尔茨海默病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]