超声观察大鼠颈总动脉机械损伤模型  

Ultrasonic observation on mechanical injury model in rat carotid artery

作　　者：刘继东[1] 崔连群[1] 耿海华[1] 张楠[2] 朱梅[2] 李锋[1] 盖玉生[1] 

机构地区：[1]山东大学山东省立医院心内科,济南250021 [2]山东大学山东省立医院心脏超声科,济南250021

出　　处：《解剖学杂志》2006年第6期770-773,共4页Chinese Journal of Anatomy

摘　　要：目的：用超声指标和病理指标评价大鼠颈总动脉机械损伤模型。方法：建立大鼠颈总动脉内皮剥脱模型,在术后1、7、28d分别超声观察颈总动脉管腔、血流速度、脉动指数(PI)和阻力指数(RI),与病理切片对照。结果：大鼠颈总动脉内皮剥脱后管腔狭窄,血流速度减慢,PI、RI增高,均于损伤第28天达峰值。结论：超声指标能够无创动态观察大鼠颈总动脉损伤及修复过程。Objective.. To evaluate the de-endothelialization model in rat carotid artery with Doppler ultrasound and pathologic analysis. Methods： The rat model was established by denuding the carotid endothelium; dynamic changes of inner diameters, hemodynamics, pulsatile index （PI） and resistance index （RI） were observed by ultrasonic technique at 1 d, 7 d and 28 d after de-endothelialization and pathology findings were compared. Results： The lu minal diameters, the maximal and minimal blood velocities were decreased after de-endothelialization, whereas the pulsatile index（H） and resistance index （RI） were increased. Conclusion： Doppler ultrasonic technique can be used to observe the injury and reparation of rat carotid artery after de-endothelialization.

关 键 词：颈总动脉 创伤和损伤 超声技术 

分 类 号：R-332[医药卫生]