雌性激素对雌性荷瘤小鼠免疫功能及实验性肺转移的影响  

Effect of diethylstilbestrol (DES) on immune function of mice-bearing tumor and its anti-metastatic effect

作　　者：汪思应[1] 姚立人[1] 张宝霆[1] 程洁[1] 

机构地区：[1]安徽医科大学病理生理学教研室

出　　处：《中国药理学通报》1996年第5期459-460,共2页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金

摘　　要：己烯雌酚（ＤＥＳ）皮下注射于荷瘤（Ｌｅｗｉｓ肺癌，ＬＬＣ）小鼠１５ｄ或２５ｄ，其巨噬细胞（ＭＯ）吞噬功能明显增强；脾细胞对ＣｏｎＡ刺激转化能力提高；脾脏重量增加；抗体产生能力增强。与对照组比较差异均有显著性（Ｐ＜０．０５）。进一步研究发现ＤＥＳ处理后，ＬＬＣ实验性肺转移结节明显减少。After injection of DES into mice-bearing Lewis Lung Carcinoma (LLC) by sc, the immune function of the mice, including macrophage(MΦ) function antibody production and proliferative responces of lymphocyte to ConA were significantiy promoted. The weight of murine spleen was increased. The number of pulmonary metastic nodules in the mice injected LLC by iv was markly decreased.

关 键 词：雌激素 淋巴细胞 转化率 转移 肺癌 巨噬细胞 

分 类 号：R734.203[医药卫生—肿瘤] R73－37[医药卫生—临床医学]