高度近视眼角膜中央厚度与眼压、屈光度和眼轴的关系  

Correlation of central corneal thickness and intraocular pressure,refraction and ocular axial length in high myopic eyes

作　　者：龙登虹[1] 欧波[1] 李忠[1] 

机构地区：[1]海南省人民医院眼科,中国海南省海口市570102

出　　处：《国际眼科杂志》2006年第6期1441-1443,共3页International Eye Science

摘　　要：目的:探讨眼角膜中央厚度(CCT)与眼压(IOP)、屈光度和眼轴之间的关系。方法:高度近视126例252眼,行CCT、IOP、屈光度和眼轴检查,并对所得数据行方差分析、直线回归分析和Kruskal-Wallis检验。根据角膜中央厚度分4组:1组480μm≤CCT<500μm,12眼;2组500μm≤CCT<550μm,135眼;3组550μm≤CCT<600μm,83眼;4组CCT≥600μm,22眼;计算相对应的眼压值,并行方差分析、直线回归分析。根据近视屈光度不同分为4组,即按等效球镜分为:1组-6.00D≤屈光度<-7.00D,72眼;2组-7.00D≤屈光度<-8.00D,80眼;3组-8.00D≤屈光度<-9.00D,48眼;4组≥-9.00D,52眼。分别计算其相对应的IOP、CCT和眼轴平均值,对获得的数据行方差分析、直线回归分析。根据眼轴不同分为4组,即1组23mm≤眼轴<24.2mm,54眼,2组24.2mm≤眼轴<25.5mm,92眼,3组25.5mm≤眼轴<26.7mm,67眼,4组26.7mm≤眼轴<28mm,39眼。分别计算其相对应的IOP、CCT和屈光度平均值,并行Kruskal-Wallis检验。结果:CCT与IOP呈正相关关系,回归方程为Y=-0.7527352+0.0373008X(CCT为X,IOP为Y),t=8.4044,P=0.00。根据CCT分4组的IOP分别为11.22±1.22,11.96±2.15,13.61±2.38和15.98±3.37mmHg,方差分析F=24.73,P=0.00001,各组间比较除1组与2组间差异无显著性外,余各组间比较差异均有非常显著性(P<0.01)。根据近视屈光度分4组的IOP分别为12.76±2.31,13.10±2.71,12.28±2.90和12.951±2.69mmHg。方差分析F=1.02,P=0.3844>0.05,各组间差异无统计学意义;4组CCT分别为547.4±30.4,547.6±35.6,539.6±29.3和544.6±33.2μm,方差分析F=0.73,P=0.5360>0.05,各组间比较无显著性意义,CCT与近视屈光度之间没有相关性。根据眼轴分组,各组间比较CCT、IOP与眼轴之间在统计学上没有差异,与眼轴的变化没有关系。随眼轴的增长,屈光度逐渐增加。结论:高度近视眼IOP与CCT密切相关,当CCT>550μm时,尤为明显,随CCT增加IOP增加;CCT与屈光度、眼轴之间没有关联;IOP与屈光度之间也没有相关性;当高度�AIM： To investigate the correlation of central corneal thickness （CCT） and intraocular pressure （IOP） and refraction in high myopic eyes. METHODS： The C/3T and ocular axial length were measurecl by ultrasonic, IOP by non-contact tonometer, refraction by keratometer in 252 eyes of 126 cases with high myopias, respectively. The results were tested by analysis of variance and linear regression. The 252 eyes were divided into four groups depending on CCT： 12 eyes in group 1 （480μm〈 CCT〈500μm）, 135 eyes in group 2 （500μm〈CCT〈 550μm）, 83 eyes in group 3 （550μm〈CCT〈600μm） and 22 eyes in group 4 （CCT≥6001μm）. The data were divided into four groups depending on refractive diopter： 72 eyes in group Ⅰ （-6.00-7.00D）, 80 eyes in group Ⅱ（-7.00--8.00D）, 48 eyes in group Ⅲ（-8.00-9.00 D） and 52 eyes in group Ⅳrefractive （diopter≥-9.00D）. The data were also divided into four groups depending on ocular axial length： 53 eyes in group A （23-24.2mm）, 91 eyes in group B （24.3-25.5mm）, 67 eyes in group C （25.6-26.7mm） and 43 eyes in group D（26.8-28mm）. All data were tested by analysis of variance. RESULTS： There was positive correlation between CCT and IOP in myopia： taking CCT as X and IOP as Y, a linear regression formula Y=-7.527352＋ 0.0373008X was concluded （t = 8.40=H, P=-0.00）. There was significant difference between groups except between groups 1 and 2 （P〉0.05） depending on the result of analysis of variance （P=- 0.00001）. There was no correlation between CCI and refraction in myopia （t=0.09, P〉0.05）. The mean value of IOP were （12.76± 2.31）mmHg, （13.10± 2.71）mmHg, （12.28± 2.90）mmHg and （12.95± 2.60）mmHg in the four groups. There was no significant difference between groups depending on the result of analysis of variance （F=-1.02, P 〉0.05）. The mean CCT were （547.43± 30.43）μm, （547.57± 35.59）μm, （539.62± 39.26）μm and （544.59± 33.17）μm in the four groups.

关 键 词：高度近视 眼压 角膜中央厚度 

分 类 号：R778.11[医药卫生—眼科]