准分子激光角膜上皮下磨镶术中应用丝裂霉素C预防Haze的早期临床观察  

Clinical observation of the application of mitomycin C in LASEK to prevent Haze

作　　者：付玲玲[1] 李桂芳[1] 张恒俊[1] 陈鑫[1] 

机构地区：[1]中国新疆维吾尔自治区克拉玛依市中心医院五官科,834000

出　　处：《国际眼科杂志》2006年第6期1472-1473,共2页International Eye Science

摘　　要：目的:探讨准分子激光角膜上皮下磨镶术中联合应用丝裂霉素C预防术后上皮下浑浊(Haze)的发生。方法:患者42例(84眼)分为A、B两组,A组右眼进行常规LASEK手术,不用丝裂霉素C;B组左眼常规LASEK手术+0.2g/L丝裂霉素C棉片于激光治疗区12～15s,术后随访6mo。结果:A组出现1级Haze18例,2级或以上Haze5例,Haze发生率55%;B组出现1级Haze7例,2级或以上Haze2例,Haze发生率21%,两组Haze发生率差异有统计学意义(P<0.001)。结论:LASEK手术中联合应用0.2g/L丝裂霉素C可降低Haze的发生率同时减轻Haze的程度,但是其更远期的疗效及副反应有待于进一步的观察。AIM： To discuss the happen of Haze after prevented treatment of LASEK combined with mitomydn C. METHODS： Forty-two cases （84 eyes） were divided into two groups： group A and B. The right eyes of the cases in group A were treated by LASEK only while the left eyes in group B were treated by LASEK and mitomycin C （0.2g/L） for !2-15 seconds. RESULTS： In group A, grade ⅠHaze in 18 eyes, gradeⅡ or over grade ⅡHaze in 5 eyes and the originating rate of Haze was 55%; Meanwhile, In group A, grade Ⅰ Haze in 7 eyes, grade Ⅱ or over grade ⅡHaze in 2 eyes and the originating rate of Haze was 21%. There was no significantly different on originating rate of Haze between group A and B（P 〈0.001 ）. OONCLUSION： The method of treating eyes by LASEK and mitomycin C （0.2g/L） is effective on easing the Haze degree, but further discussion is needed on its curative effect and side effect.

关 键 词：准分子激光角膜上皮下磨镶术 丝裂霉素C 上皮下浑浊 

分 类 号：R779.63[医药卫生—眼科]