五种中草药对钙通道阻滞作用的初步研究  

Preliminary study on calcium channel blocking effects of 5 Chinese herbs

作　　者：苏金平 刘干中[2] 彭继道 

机构地区：[1]广州市施柏医药科技有限公司,广州510176 [2]北京中日友好医院,北京100029

出　　处：《中药药理与临床》2006年第6期45-47,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:初步研究黄芩、牛膝、杜仲、山楂、豨莶草五种中草药对血管平滑肌细胞(VSMCs)钙通道的影响。方法:大鼠离体胸主动脉环观察对去甲肾上腺素(NA)诱导的内钙依赖性与外钙依赖性缩血管作用的影响。结果:上述五种药材均能不同程度的抑制NA诱导的细胞外Ca2+内流产生的血管平滑肌的收缩;其中黄芩还能够显著地抑制NA诱导的细胞内"钙储库"中Ca2+的释放。结论:五种药材对VSMCs钙通道具有阻滞作用,这可能与其扩张血管、降血压作用机制有关;其中牛膝、杜仲、山楂和豨莶草等对VSMCs钙通道的阻滞作用为首次研究发现。Objective： To study the vasodilatation and calcium channel blocking effects of Skullcap Root, Twotooth Achyranthes Root, Eucommia Bark, hawthorn fruit and Siegesbechia herb. Methods ： Observed the inhibitory effects of the 5 Chinese herbs on NA-indueed contraction, either due to calcium release from internal stores or inward Ca^2＋ , of thoracic aortic rings isolated fi＇om SD rats. Results ： The 5 Chinese herbs have extracellular calcium entry blocking effect. Furthermore, Skullcap Root can significant inhibit intracellular stores calcium release as well. Conclusion： These Chinese herbs have calcium channel blocking effects in VSMCs, which may associate with their vasodilatation and anti-hypertensive effects.

关 键 词：黄芩 牛膝 杜仲 山楂 稀莶草 钙通道阻滞 

分 类 号：R285[医药卫生—中药学]