Fasl在胃癌中的表达及临床意义  

Expression and clinical significance of fasl gene in gastric cancer

作　　者：季枚[1] 吴昌平[1] 赵伟庆[1] 谈敏[1] 谈炎[1] 陈同玨 

机构地区：[1]常州市第一人民医院肿瘤科,江苏常州213003

出　　处：《中华肿瘤防治杂志》2006年第20期1568-1570,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨胃癌组织中凋亡因子(Fasl)的表达及其与各临床病理因素的关系,评价Fasl在胃癌预后判断中的价值。方法:应用免疫组织化学Elivision法检测102例胃癌组织中Fasl的表达情况,回顾性分析Fasl与各临床病理因素及预后之间的关系。结果:胃癌组织中Fasl表达阳性率为69/102(67·6%)。低分化型胃癌的Fasl表达阳性率12/29(41·3%)明显低于分化型胃癌的阳性表达率52/73(71·2%),P<0·05;生存期<2年的患者胃癌组织中Fasl表达阳性率48/51(94·1%)明显高于生存期>5年患者的阳性表达率21/51(41·2%),P<0·01。此外Fasl表达阳性率在肿瘤部位、浸润深度及肿瘤大小等方面差异不明显,P>0·05。结论:凋亡因子Fasl在胃癌组织中具有较高的表达率,其表达与胃癌的分化类型相关。Fasl的表达状态是胃癌根治术后重要的预后因素,高表达提示预后不良。OBJECTIVE.. To investigate the relationship between the expression of fasl and the clinicopathologic parameters in gastric carcinoma, and evaluate its significience in predicting the prognosis. METHODS： The immunohistochemical method by Ellvision was used to detect fasl expression in 102 patients with gastric carcinoma. The relationship among fasl expression and the clinicopathologic parameters and prognosis was retrospectively analyzed. RESULTS： Fas1 expression was positive in 69 of 102 cases （67.6% ）. The positive rate of the expression in cases of well-differentiated metastasis was bighter than that in cases of poor-differentiated group （41.3% vs 71.2% ,P〈0. 05）, being as well as the survival time （〈2 years vs 〉5 years 94.1% vs 41.2%, P〈0.01）. There was no significant difference in the tumor site, tumor size and the depth of tumor invasion. CONCLUSION： Up-regulated expres- sion of apoptosis factor fasl can be found in gastric carcinoma. Fas1 expression is significantly correlated with tumor differentiation. Fas1 is an independent predictor for the patients with gastric carcinoma after radical resection.

关 键 词：胃肿瘤/病理学 细胞凋亡 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]