p57^(kip2)蛋白和增殖细胞核抗原在喉鳞癌组织中的表达及其临床意义探讨  

Expressions of p57^(kip2) and PCNA in laryngeal squamous cell carcinoma and their clinical significance

作　　者：温晓霞[1] 马福伟[1] 季文樾[2] 

机构地区：[1]中国医科大学附属第四医院耳鼻喉科,辽宁沈阳110032 [2]中国医科大学附属第一医院耳鼻喉科,辽宁沈阳110001

出　　处：《中华肿瘤防治杂志》2006年第19期1472-1474,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的探讨细胞周期调控抑制因子蛋白p57kip2和增殖细胞核抗原PCNA在喉鳞癌(LSCC)中的表达及临床意义。方法采用免疫组织化学技术SP法,检测p57kip2和PCNA在40例喉鳞癌组织和癌旁组织的表达情况。结果在喉鳞癌组织中p57kip2阳性率(42.5%)低于癌旁组织(72.5%),并与TNM分期、癌组织分化程度、淋巴结转移呈负相关;PCNA阳性率(55.0%)明显高于癌旁组织(30.0%),并与TNM分期、癌组织分化程度、淋巴结转移呈正相关;p57kip2+与p57kip2-患者生存期≥5年的比率分别为76.5%和19.1%;PCNA+与PCNA-患者生存期≥5年的比率分别为40.1%和72.2%。结论p57kip2和PCNA分别是喉鳞状细胞癌进展及预后判断的独立指标;p57kip2在喉鳞癌中的不同表达水平可能与不同的调控方向有关。OBJECTIVE： To study the significance of expressions of p57^kip2 and proliferating cell nuclear antigen（PCNA）in laryn geal squamous cell carcinoma （LSCC）. METHODS： p57^kip2 and PCNA were analysed by using SP immunohistochemistry technique in tumor and adjacent tissues. RESULTS： Of the LSCC： the positive rate of p57^kip2 was 42.5% which was significantly lower than that of adjacent tissues （72.5%）. The expression of p57^kip2 was negatively correlated with TNM stage, tumor cell differentiation, lymph node metastasis and prognosis. The positive rate of PCNA was 55.0% which was significantly higher than that of adjacent tissues （30. 0%）. The expression of PCNA was correlated with TNM stage, tumor cell differentiation, lymph node metastasis and prognosis. The rates of survival time≥5years of patients with p57^kip2 positive and p57^kip2 negative were 76.5% and 39.1%, respectively. The rates of survival time≥5 years of patients with PCNA positive and PCNA negative were 40.1% and 72.2%, respectively. CONCLUSION： p57^kip2 and PCNA were independent markers of progression and prognosis of patients with LSCC. Different expression levels of p57^kip2 in LSCC are probably related with different regulating directions.

关 键 词：喉肿瘤/免疫学 癌 鳞状细胞/免疫学 核蛋白质类/生物合成 增殖细胞核抗原/分析 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤]