恶性纤维组织细胞瘤的预后因素分析  

Analysis of prognosis in 39 patients with malignant fibrous histiocytoma

作　　者：彭瑛[1] 李昉[1] 吴双[1] 刘燕[1] 王冀川[1] 王捷[1] 

机构地区：[1]四川省肿瘤医院放疗科,四川成都610041

出　　处：《中华肿瘤防治杂志》2006年第19期1504-1506,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的回顾性分析39例恶性纤维组织细胞瘤(malignantfibroushistiocyto-ma,MFH)的治疗结果和影响预后的因素。方法39例患者中,6例为首程治疗病例,33例为院外局部手术后复发病例。其中单纯手术18例(3例加用化疗),手术+术后放射治疗21例(4例加用化疗)。结果全组病例5年生存率53.4%。非黏液囊性肿瘤和黏液囊性肿瘤的5年生存率分别为31.8%和74.2%,P=0.0001。发病部位四肢与非四肢的5年生存率分别为60.0%和47.6%,P=0.33。手术+术后放疗组与单纯手术组5年生存率分别为76.1%、31.1%,P=0.015。根治手术和包块局部切除术的5年生存率为66.7%和43.8%,P=0.219。年龄≤60和>60岁治疗后生存率分别为37.5%和68.9%,P=0.017。男性和女性的5年生存率分别为47.8%和75.0%,P=0.448。肿瘤最大直径≤5和>5cm者5年生存率分别为86.2%和35.7%,P=0.0004。结论MFH经完整或扩大切除术加术后放射治疗可以明显提高其生存率,病理类型、肿瘤大小、治疗方式与患者治疗后的生存率密切相关。OBJECTIVE： To evaluate the treatment results and prognostic factors of malignant fibrous histioeytoma （MFH）. METHODS： 39 patients with MFH were retrospectively analyzed, and among them 6 patients were referred to our hospital for primary treatment and the remaining 33 patients came with recurrent disease. Surgery （S） alone was performed in 18 eases （including 3 cases with chemotherapy）, S＋ postoperative radiotherapy （R） in 21 cases （including 4 cases with chemotherapy）. RESULTS： The 5- year accumulated survival rate of the whole group was 53.4%. The 5-year survival rates of tumor histology （myxoid vs nonmyxoid） were 74, 2% and 31.8% respectively, with P value 0. 000 1. The 5-year survival rates of tumor site（extremity vs nonextremity） were 60.0%, 47.6% respectively, with P value 0. 33. The5 yearsurvivals of different treatment methods were： S＋R 76, 1%, surgery alone 31. 1%, with P-value 0.015; radical resection 66.7%, local excision 43.8%, with P=0. 219. The 5-year survival rates of age≤60yr and 〉60yr were 37.5% and 68.9% respectively, with P 0. 017. The 5 year survival rates of male and female were 47.8% and 75.0% respectively, with P 0.448. The 5-year survival rates of patients with tumor diameter ≤ 5 and 〉5 cm were 86.2% and 35.7% respectively, with marginal significant difference, P = 0. 000 4. CONCLUSIONS： Complete or extended resection followed by radiotherapy is recommended for MFH. The tumor histology （myxoid vs. nonmyxoid）, size （≤5 vs 〉5 cm） and treatment method were prognostic factors.

关 键 词：组织细胞瘤 纤维 巨细胞瘤 骨/治疗应用 预后 

分 类 号：R738[医药卫生—肿瘤]