CD14与酒精性肝病  

Role of CD14 in alcoholic liver disease

作　　者：吴涛[1] 季光[1] 郑培永[1] 

机构地区：[1]上海中医药大学附属龙华医院肝病研究室,上海市200032

出　　处：《世界华人消化杂志》2006年第35期3341-3347,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助课题;No.30572380~~

摘　　要：白细胞分化抗原14(clusterofdifferentiationantigen,CD14)为内毒素脂多糖(lipopolysac-charide,LPS)高亲和力受体,在机体免疫、防御系统引起的一系列反应中起着关键的作用.细胞膜CD14识别LPS并引起细胞酪氨酸磷酸化、核因子(nuclearfactor-κB,NF-κB)转位、触发细胞因子释放和氧自由基的产生.而可溶性CD14则与细胞膜CD14竞争结合LPS,并且介导不表达膜CD14的内皮细胞和平滑肌细胞对LPS的应答.近年来发现,CD14在酒精性肝病的发病机制中起着重要的作用.CD14 （cluster of differentiation antigen）, the receptor of LPS （lipopolysaccharide）, plays a key role in a series of responses of the body immune and recovery system. Membrane CD14 not only recognizes LPS, but also induces tyrosine＇s phosphorylation, transposes NF-kB （nuclear factor-kB）, triggers the release of cytokines, generates the oxygen free radicals. But the soluble CD14 competes with membrane CD14 in binding LPS, and mediates the response to LPS of the endothelial cells and smooth muscle cells which do not express membrane CD14. In recent years, it is demonstrates that CD14 plays an important role in the pathogenesis of alcoholic liver disease.

关 键 词：白细胞分化抗原14 酒精性肝病 脂多糖 信号传导 发病机制 

分 类 号：R575.5[医药卫生—消化系统]