颞下颌关节紊乱病动物模型的建立及其评价  

Evaluation of a model of temporomandibular disorders established by transzygomatic arch traction of the mandibular ramus in rabbits

作　　者：刘来奎[1] 洪宇娟[1] 陶德韬[2] 李晓箐[1] 易新竹[1] 

机构地区：[1]四川大学华西口腔医学院口腔解剖生理教研室,成都610041 [2]南京医科大学口腔医学院口腔解剖生理教研室

出　　处：《中华口腔医学杂志》2006年第12期755-756,共2页Chinese Journal of Stomatology

摘　　要：目的探讨经颧弓后上牵引下颌,建立颞下颌关节紊乱病(TMD)动物模型的可能性。方法21只新西兰大白兔(实验组15只,对照组6只),单侧经颧弓后上牵引下颌,观察关节盘、关节间隙及关节软骨的组织病理学改变。结果实验组术后2周4只动物关节盘移位或变形;4周时5只动物关节均发生粘连,关节软骨发生不同程度表层破裂、缺损或排列紊乱;6周时4只动物关节盘严重变形,5只动物关节发生严重粘连,骨小梁排列紊乱。对照组均正常。结论经颧弓后上牵引下颌是研究TMD病理机制一种较可靠的动物模型。Objective To evaluate a model of temporomandibular disorders established by transzygomatic arch traction of the mandibular ramus in rabbits. Methods Fifteen adult New Zealand rabbits were subjected to traction in the postero-superior direction unilaterally using elastic force and six rabbits used as the control. Histopathologic change of the disc ,joint space and cortlage was observed through Hematoxylin and Eosin staining. Results Anterior disc displacement or disc deformity in four experimental rabbits was observed on the traction side 2 weeks after operation. At 4 weeks, fibrous adhesions in joint compartment were found in five experimental rabbits. The condyles or articular eminences of some experimental rabbits showed irregularities on the cartilage surface. In the 6 th week, bad disc deformity in four rabbits and severe fibrous adhesions in five rabbits was observed on the traction side, and subchondralbone and calcified cartilage became irregular. In control group, All articular structures were normal. Conclusions A animol model of temporomandibular disorders can be established by transzygomatic arch traction of the mandible.

关 键 词：颞下颌关节 牵引术 模型 动物 

分 类 号：R-332[医药卫生]