甲状腺肿瘤中肝细胞生长因子及其受体蛋白的表达研究  

Expressions of hepatocyte growth factor and its receptor protein in human thyroid neoplasms

作　　者：尚立芝[1] 李德祥[1] 秦俊莲[2] 

机构地区：[1]遵义医学院病理学教研室,563003 [2]河南中医学院生理学科

出　　处：《中华内分泌代谢杂志》2006年第6期570-572,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：贵州省科委资助项目(983055)

摘　　要：用免疫组化检测甲状腺良恶性肿瘤组织中肝细胞生长因子(HGF)及其受体(c-Met)的表达。结果显示HGF和c-Met蛋白阳性表达率在腺癌组中显著高于腺瘤组,尤其滤泡性腺癌组显著高于滤泡性腺瘤组,二者表达强度在乳头状腺癌组呈显著正相关。提示HGF和c-Met的异常表达可能对甲状腺良恶性肿瘤的鉴别诊断、预后判断有一定参考意义。The expressions of hepatocyte growth factor （HGF） and its receptor （c-Met） protein were examined by immunohistochemistry in benign and malignant thyroid neoplasms. The results showed that the positive rates of HGF and c-Met protein expressions in thyroid carcinomas were significantly higher than those of thyroid adenomas, and especially the expressions of HGF and c-Met proteins in follicular thyroid carcinomas were significantly higher than those in follicular thyroid adenomas. There existed significantly positive correlation between the expression degrees of HGF and c-Met in follicular thyroid carcinoma. Thus, the expressions of HGF and c-Met may be valuable in predicting prognosis of thyroid carcinomas and differentiating benign from malignant thyroid neoplasms.

关 键 词：甲状腺肿瘤 肝细胞生长因子 原癌基因蛋白质C-MET 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]