同源异型盒基因CDX1和CDX2使食管腺癌细胞恶性降低  

Homeobox genes CDX1 and CDX2 reduced malignancy of esophageal adenocarcinoma cells

作　　者：马丽萍[1] 李娜[1] 潘秀英[1] 董建强[1] 陈晓欣[1] 

机构地区：[1]北京大学人民医院中心实验室,北京100044

出　　处：《基础医学与临床》2006年第12期1319-1323,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(30171050)

摘　　要：目的探讨同源异型盒基因CDX1和CDX2对食管腺癌细胞表型的影响。方法用携带人CDX1或CDX2的表达载体转染食管腺癌细胞系SEG-1,观察形态、生长率变化、分裂指数、致瘤性等。结果CDX1或CDX2单独作用都使SEG-1出现类腺样生长排列、生长率下降、分裂指数降低、致瘤性减弱,CDX2的作用大于CDX1。结论CDX1和CDX2均能促进食管腺癌细胞SEG-1分化,减低其恶性。Objective To study the effect of homeobox genes CDXI and CDX2 on the phenotype of esophageal adenocareinoma cells. Methods Esophageal adenocarcinoma cell line SEG-1 was transfected with CDXI or CDX2 cDNA. The morphology, growth rate, division index and tumorigenicity were analyzed. Results The expression of CDXI or CDX2 leaded to occurring adeniform-like manifestation. The growth rate, division index and tumorigenicity were reduced, especially by CDX2. Conclusion CDXI and CDX2 all could increase differentiation of esophageal adenocareinoma cells and reduction of its malignancy.

关 键 词：CDX1 CDX2 食管腺癌 SEG-1 

分 类 号：R735.1[医药卫生—肿瘤]