阿立哌唑与利培酮治疗精神分裂症的对照研究  

Comparative Study on the Effect of Aripiprazole and Risperidone on Schizophrenia.

作　　者：张武文[1] 徐建国 吴国兰 

机构地区：[1]中国．秦皇岛市九龙山医院,066601 [2]不详

出　　处：《国际中华应用心理学杂志》2006年第3期296-298,共3页intermational chinaese application psychology journal

摘　　要：目的 比较阿立哌唑与利培酮治疗精神分裂症的疗效。方法 将符合中国精神疾病分类与诊断标准第三版（CCMD-3）精神分裂症标准的80例患者随机分为2组，分别予阿立哌唑（A组）和利培酮（B组）治疗8周，采用阳性症状与阴性症状量表及不良反应症状量表抨定疗效与副反应。结果 2组疗效及不良反应发生率比较差异无显著性意义。结论 阿立哌唑和利培酮对精神分裂症疗效相当，副反应差异亦不显著，但在锥体外系反应、内分泌改变及体重增加方面，阿立哌唑优于利培酮。Objective To compare the efficacy and safety of Aripiprazole and Risperidone in the treatment of schizophrenia. Methods Eighty patients with Schizophrenia by CCMD-3 were randomly allocated to two groups treated with Aripiprazole or Risperidone respectively for 8 weeks. The Positive and Negative Syndrome Scale（PANSS） and Treatment Emergent Side effect Scale （TESS） were used to evaluate the efficacy and adverse effect respectively. Results The clinical efficacy and the incidence of adverse effect in the two groups had no significant difference. Conclusion Aripiprazole is as effective and safe as Risperidone for the treatment of Schizophrenia and fewer side effect. The incidence of adverse effect in two drugs has no any significant difference. But It shows that Aripiprazole is superior to Risperidone in extrapyramidal symptoms, endocrine change and weight gain.

关 键 词：阿立哌唑 利培酮 精神分裂症 疗效 安全性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]