原发性胆汁性肝硬化血清抗线粒体抗体亚型的检测及诊断价值  

The clinical presentation of primary biliary cirrhosis and the diagnostic value of anti-mitochondrial antibody subtype

作　　者：杨新玲[1] 陈乃玲[2] 吴惠毅[1] 赵文海[1] 

机构地区：[1]连云港市第一人民医院,江苏连云港222002 [2]北京军区总医院,北京100700

出　　处：《中国实验诊断学》2006年第12期1390-1392,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨抗线粒体亚型(AMA亚型)对原发性胆汁性肝硬化(PBC)的诊断价值。方法应用酶免疫斑点法检测血清中AMA-M2、M4、M9亚型。8例经临床诊断为PBC患者,47例非PBC肝胆病患者。结果8例PBC患者M2均阳性、但M4及M9均阴性;47例非PBC肝胆病患者M2、M4、M9均阴性。4例PBC者肝活检Ⅰ期及Ⅳ期各1例、2例为Ⅱ期。结论血清AMA-M2抗体检测可作为临床诊断PBC的重要血清免疫学诊断指标。Objective This is a study on the dianostic value of anti-mitochondrial antibody subtype （AMA-M2.M4 and M9） in the patients of primary biliary cirrhosis （PBC）.Methods The enzyme immunc blot assay were used for the detection of AMA-M2, M4 and M9 antibodies in 8 PBC patients diagnosed by clinical presentation and 47 patients with other hepato-biliary discases as control Results All the 8 PBC patients diagnosed by clinical presentation were found to be M2 antibody positive while the M4,M9 were all negative. The 47 patients with other hepato-biliary diseases were all negative in AMA- M2, M4 and M9 antibedies. In the 4 of the 6 PBC patients who lind received liver biopsy 2 patients were found to be in stage Ⅱ of PBC,one by one patient in stage Ⅰ and Ⅳ. Conclusion AMA-M2 antibody detection is an important and sencetive seroimmunological marker for the diagnosis of PBC.

关 键 词：原发性胆汁性肝硬化 抗线粒体抗体M2亚型 酶免疫斑点法 肝活检 诊断指标 

分 类 号：R575.22[医药卫生—消化系统]