低剂量丝裂霉素C辐射防护作用的初步研究  

Effect of Low Dose Mitomycin C on radio protective Function

作　　者：高峰[1] 孙晓玲[2] 王彬[2] 梁硕[2] 张海英[2] 

机构地区：[1]吉林省疾病预防控制中心,吉林长春130062 [2]吉林大学公共卫生学院,吉林长春130021

出　　处：《中国实验诊断学》2006年第12期1475-1476,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的观察丝裂霉素C(MMC)对辐射损伤小鼠染色体畸变的影响。方法小鼠腹腔注射低剂量MMC,再给大剂量X射线照射,或先给大剂量X射线照射再给低剂量MMC。观察小鼠骨髓细胞染色体畸变。结果所有低剂量MMC处理组小鼠骨髓细胞染色体畸变率均低于单纯大剂量照射组。结论低剂量MMC可以减轻辐射所致的染色体损伤,具有辐射防护作用。Objective To study effect of low dose Mitomycin C （MMC） on chromosome aberration of bone marrow ceils of mice treated by 2.0Gy X ray. Methods The mice were treated by low dose MMC before or after treated by high dose X-ray. And chromosome aberration of bone marrow ceils of mice was observed. Results The chromosome aberration in all the group of treated by low dose MMC was lower than that in the 2Gy X-my group. Conclusion Low dose MMC has a better radiation prevention effect.

关 键 词：丝裂霉素C 染色体畸变 辐射防护 

分 类 号：R144[医药卫生—公共卫生与预防医学]