心血管组织内的成纤维细胞之信息传递  

Fibroblast Cell Signaling in Cardiovascular Tissues

作　　者：郑志鸿[1] 关超然[1] 张永贤[1] 

机构地区：[1]中国医药大学,台湾

出　　处：《华夏医药》2006年第6期415-417,共3页Hua-xia Medicine

摘　　要：心血管组织，纤维细胞的增生与细胞外基质的生合成于心血管重塑过程中扮演重要的角色，在报告中探讨生长因子如血管收缩素及内皮素在心脏纤维细胞增生所扮演的角色，深入分析纤维细胞中内皮素基因表现的调控机制，特别着重于有关细胞内活性氧族群于纤维细胞内信息传递过程中所扮演的角色。这样的机制也存在于血管外周的纤维细胞而造成在高血压及糖尿病中血管壁结缔纤维组织的增生及硬化．In cardiovascular tissues, fibro blasts play a central and dynamic role in the remodeling process, which includes proliferation of fibroblasts, and changes in the extent and composition of the synthesis of extra-cellular matrix proteins. In this report, we discuss the role of angiotensin Ⅱ and endothelin-1 on fibroblast proliferation and endothelin-1 gene induction, focusing especially on reactive oxygen species-mediated signaling in cardiac fibroblasts. This angiotensin mediated mechanism in fibrobalst on the structural changes also occur in blood vessels and may be responsible for the vascular remodeling and functional changes of blood vessels in cardiovascular diseases, including hypertension and diabetes mellitus.

关 键 词：细胞内信息传递 成纤维细胞 心血管组织 组织内 纤维细胞增生 心血管重塑 细胞外基质 血管收缩素 

分 类 号：R735.7[医药卫生—肿瘤]