多中心、随机、开放性观察思吉宁治疗帕金森病的临床疗效及安全性  被引量：3

THE EFFICACY AND SAFETY OF SELEGILINE IN TREATMENT OF PARKINSON’S DISEASE: MULTI-CENTER, RANDOMIZED AND OPEN CLINICAL TRIAL</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=23505958' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('NeAwqCx3kFUF9/6GTifMiMzOxljBka1KSd18s8UAR9Y=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="NeAwqCx3kFUF9/6GTifMiMzOxljBka1KSd18s8UAR9Y="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" 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title='黄鉴政[3]'>黄鉴政[3]</a> <a href='/writer/article.aspx?id=100000011605065' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e4%b8%81%e6%96%b0%e7%94%9f%5d' title='丁新生[4]'>丁新生[4]</a> <a href='/writer/article.aspx?id=100000005226416' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%83%ad%e6%98%8e%e5%85%89%5d' title='郭明光[5]'>郭明光[5]</a> <a href='/zk/search.aspx?key=A%3d%5b%e8%8b%8f%e6%83%a0%e7%90%b3%5d' title='苏惠琳'>苏惠琳</a> <a href='/writer/article.aspx?id=100000003219421' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e7%91%9b%5d' title='王瑛[1]'>王瑛[1]</a> <a href='/writer/article.aspx?id=100000009617847' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%92%8b%e9%9b%a8%e5%b9%b3%5d' title='蒋雨平[2]'>蒋雨平[2]</a> <a href='/writer/article.aspx?id=100000006739948' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%af%9b%e5%96%84%e8%8b%b1%5d' title='毛善英[3]'>毛善英[3]</a> <a href='/writer/article.aspx?id=100000002414024' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%91%a3%e6%b5%b7%e8%93%89%5d' title='董海蓉[4]'>董海蓉[4]</a> <a href='/writer/article.aspx?id=100000012151648' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e6%99%ba%e6%a8%b1%5d' title='王智樱[5]'>王智樱[5]</a> <a href='/writer/article.aspx?id=100000011523374' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%99%88%e7%94%9f%e5%bc%9f%5d' title='陈生弟[1]'>陈生弟[1]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=2831&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e4%b8%8a%e6%b5%b7%e4%ba%a4%e9%80%9a%e5%a4%a7%e5%ad%a6%e9%99%84%e5%b1%9e%e7%91%9e%e9%87%91%e5%8c%bb%e9%99%a2%e7%a5%9e%e7%bb%8f%e5%86%85%e7%a7%91' title='[1]上海交通大学附属瑞金医院神经内科,200001'>[1]上海交通大学附属瑞金医院神经内科,200001</a> <a href='/organ/article.aspx?id=2601075&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%a4%8d%e6%97%a6%e5%a4%a7%e5%ad%a6%e9%99%84%e5%b1%9e%e5%8d%8e%e5%b1%b1%e5%8c%bb%e9%99%a2%e7%a5%9e%e7%bb%8f%e7%a7%91' title='[2]复旦大学附属华山医院神经科'>[2]复旦大学附属华山医院神经科</a> <a href='/organ/article.aspx?id=3567&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%b5%99%e6%b1%9f%e5%a4%a7%e5%ad%a6%e5%8c%bb%e5%ad%a6%e9%99%a2%e9%99%84%e5%b1%9e%e7%ac%ac%e4%ba%8c%e5%8c%bb%e9%99%a2%e7%a5%9e%e7%bb%8f%e7%a7%91' title='[3]浙江大学医学院附属第二医院神经科'>[3]浙江大学医学院附属第二医院神经科</a> <a href='/organ/article.aspx?id=1221&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%b1%9f%e8%8b%8f%e7%9c%81%e4%ba%ba%e6%b0%91%e5%8c%bb%e9%99%a2%e7%a5%9e%e7%bb%8f%e7%a7%91' title='[4]江苏省人民医院神经科'>[4]江苏省人民医院神经科</a> <a href='/organ/article.aspx?id=1764&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e4%b8%8a%e6%b5%b7%e4%ba%a4%e9%80%9a%e5%a4%a7%e5%ad%a6%e5%8c%bb%e5%ad%a6%e9%99%a2%e9%99%84%e5%b1%9e%e4%bb%81%e6%b5%8e%e5%8c%bb%e9%99%a2%e7%a5%9e%e7%bb%8f%e7%a7%91' title='[5]上海交通大学医学院附属仁济医院神经科'>[5]上海交通大学医学院附属仁济医院神经科</a> <a href='/zk/search.aspx?key=S%3d%e6%b5%99%e6%b1%9f%e7%9c%81%e6%b9%96%e5%b7%9e%e4%b8%89%e9%99%a2%e7%a5%9e%e7%bb%8f%e7%a7%91' title='[6]浙江省湖州三院神经科'>[6]浙江省湖州三院神经科</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=81670X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e8%80%81%e5%b9%b4%e5%8c%bb%e5%ad%a6%e4%b8%8e%e4%bf%9d%e5%81%a5%5d' title='老年医学与保健'>《老年医学与保健》</a>2006年第4期214-217,共4页<em>Geriatrics & Health Care</em></p><p class='abstrack'><strong>摘　　要：</strong>目的研究单胺氧化酶B(MAO-B)抑制剂思吉宁治疗帕金森病(PD)的临床疗效和安全性。方法采用多中心、随机、开放性对照试验,对140例PD患者随机分为两组,分别服用思吉宁或维生素E12周,比较两组用药第4、8、12周末UPDRS评分和用药第12周汉密尔顿抑郁量表(HMD)评分下降程度,评估其治疗效果,同时记录试验过程中可能发生的不良反应。结果思吉宁组在用药第4、8、12周末的UPDRS评分下降与维生素E组比较有统计学意义(P<0.01)。思吉宁组在改善患者UPDRS评分方面的有效率高于维生素E组。常见不良反应为纳差、恶心等消化道症状和头晕。而失眠、体位性低血压虽少见,却容易导致停药。结论思吉宁作为MAO-B抑制剂是治疗PD的有效药物,耐受性良好。<em>Objective To investigate the efficacy and safety of Selegiline, one of the monoamine oxidase type B （MAOB） inhibitors, in the treatment of Parkinson＇ s disease （PD）. Methods The multi-center, randomized and open clinical trial was performed in the present study. 140 patients with idiopathic PD were divided randomly into 2 groups, i.e., Selegilinetrealed group（u=69） and Vitamine E-treated group （n=71）. lasting for 12 weeks. The efficacy was evaluated by the Unified Parkinson＇s Disease Rating Scale （UPDRS） scores and Hamilton Depression Raling Scale （HMD） scores. The side reactions were also recorded. Results The significant reduction of UPDRS scores in Selegiline-treated group was found at the end of the 4th, 8th and 12th weeks, compared with that of the Vitamine E-treated group,（P〈0.01）. The HMD scores examined at the 12th week were not changed. Cardinal side effects were digestive tract discomfort, dizziness, sleeplessness and postural hypotension. Conclusions Selegiline has a satisfactory effect and tolerance on the management of PD symptoms.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=37886' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%8d%95%e8%83%ba%e6%b0%a7%e5%8c%96%e9%85%b6%e6%8a%91%e5%88%b6%e5%89%82%5d' title='单胺氧化酶抑制剂'>单胺氧化酶抑制剂</a> <a href='/subject/article.aspx?id=2853679' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%5d' title='帕金森病'>帕金森病</a> <a href='/subject/article.aspx?id=6518159' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%a4%9a%e4%b8%ad%e5%bf%83%e7%a0%94%e7%a9%b6%5d' title='多中心研究'>多中心研究</a> <a href='/subject/article.aspx?id=7328455' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%ae%89%e5%85%a8%e6%80%a7%5d' title='安全性'>安全性</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR742.5' title='R742.5'>R742.5</a>[<a href = '/domain/article.aspx?id=504' >医药卫生—神经病学与精神病学</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=23505958" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=23505958"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); 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