A型肉毒毒素治疗痉挛型脑瘫用药剂量分析  

Optimal Dose of Botulinum Toxic A in Treatment of Spastic Cerebral Palsy

作　　者：刘建军[1,2] 纪树荣[1,2] 胡莹媛[1,2] 李燕春[1,2] 吴卫红[1,2] 陆华宝[1,2] 张雁[1,2] 

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]北京博爱医院,北京市100068

出　　处：《中国康复理论与实践》2006年第10期831-832,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的 探讨A型肉毒毒素（BTX-A）阻滞术缓解脑瘫患儿痉挛的最佳用药剂量。方法 对61例痉挛型脑瘫患儿（年龄27～144个月）采用BTX-A阻滞术治疗，按BTX-A剂量系数将患儿分为A、B、C、D、E5组，根据Ashworth评分和体重每次用量为30～160IU，平均（69．0±32．4）IU。结果 55人次接受BTX-A阻滞术治疗后肌张力有所下降，功能有所提高，有效率为90．16％，疗效持续时间8～32周，平均（17．56±8．30）周。C组（2≤剂量系数〈3）的疗效持续时间最长。结论 最佳的小腿三头肌的BTX-A用药剂量计算公式为：剂量（IU）=（修改的Ashworth评分＋2．5）×体重（kg）。Objective To investigate the optimal dose of botulinum toxic A （BTX-A） block to relax spasticity in cerebral palsy. Methods 61 children （27-144 months old） with spastic cerebral palsy were treated by BTX-A block and divided into A, B, C, D and E groups according to the dose coefficient. The dose of BTX-A block was 30-160 IU （average 69.0±32.4 IU） according to the weight and the score of Modified Ashworth Scale. Results 55 BTX-A blocks were successful. The muscles tone turned below and the function were improved. The effective rate was 90.16%. The effective time ranged from 8 weeks to 32 weeks, average 17.56±8.30 weeks. The effective time of the group C （2≤dose-coefficient〈3） was the longest in the five groups. Conclusion The optimal dose of BTX-A block in triceps surae should be counted as follow： dose（IU）-（score of Modified Ashworth Scale＋2.5）×weight（kg）.

关 键 词：脑性瘫痪 痉挛 A型肉毒毒素 剂量 神经阻滞 

分 类 号：R742.3[医药卫生—神经病学与精神病学]