Gal-3和Bcl-2蛋白的表达与垂体腺瘤侵袭性的关系  

Expressions of Gal-3 and Bcl-2 and their relationship with the invasiveness in pituitary adenomas

作　　者：刘志雄[1] 侯永宏[1] 黄垂学[1] 刘运生[1] 傅春燕[2] 

机构地区：[1]中南大学湘雅医院神经外科,湖南长沙410008 [2]中南大学湘雅医院病理科,湖南长沙410008

出　　处：《中国耳鼻咽喉颅底外科杂志》2006年第6期422-425,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的探讨半乳糖凝集素-3(Gal-3)和细胞淋巴瘤/白血病基因-2(Bcl-2)蛋白水平的表达与垂体腺瘤侵袭性的关系。方法采用免疫组化S-P法检测31例非侵袭性和47例侵袭性垂体腺瘤组织中Gal-3和Bcl-2的蛋白表达。结果侵袭性垂体腺瘤组的Gal-3和Bcl-2的蛋白表达均较非侵袭性腺瘤组显著增高(P<0.01)。侵袭性腺瘤组中Gal-3和Bcl-2的表达水平成正相关(P<0.01)。结论侵袭性垂体腺瘤的生物学行为与Gal-3和Bcl-2的表达增高有相关性。Gal-3和Bcl-2在抗凋亡过程中可能存在着内在联系。Objective To detect the expressions of Gal-3 and Bcl-2 in pituitary tumors and explore the relationship between the expressions of Gal-3 and Bcl-2 and the invasiveness of pituitary adenomas. Methods The expressions of Gal-3 and Bcl-2 were detected in 31 non-invasive pituitary adenomas and 47 invasive pituitary adenomas by using immunohistochemlcal S-P assay. The correlation between the expressions of Gal-3, Bcl-2 and tumor invasiveness were studied. Results Compared with the non-invasive pituitary adenomas, the expressions of Gal-3 and Bcl-2 increased in invasive ones （ P 〈0. 01）. There was a positive correlation between Gal-3 and Bcl-2 at protein level. Conclusion The increased expressions of Gal-3, Bel-2 are significantly correlated with the invasiveness of pituitary adenomas, and they may play an ingenerate role in the invasiveaaess and the apoptosis of this tumor.

关 键 词：垂体腺瘤 GAL-3 BCL-2 侵袭性 凋亡 

分 类 号：R736.4[医药卫生—肿瘤]