犬下颌骨节段性缺损的个体化再生修复实验研究  

Experimental Study on Individualized Reconstruction of Mandibular Segmental Defect in Dogs

作　　者：张庆福[1] 吕春堂[2] 刘国勤[1] 罗小龙[2] 汪大林[2] 周中华[2] 

机构地区：[1]解放军第四一一医院口腔专科中心,上海200081 [2]第二军医大学长海医院口腔科,上海200433

出　　处：《口腔颌面外科杂志》2006年第4期313-316,共4页Journal of Oral and Maxillofacial Surgery

摘　　要：目的:通过实验观察犬下颌骨节段性缺损个体化再生修复的效果,为计算机辅助个体化再生修复下颌骨缺损的技术和方法向临床过渡提供依据。方法:利用计算机辅助设计/制作、快速原型技术等设计制作实验动物下颌骨个体化三维中空钛网修复体,再将其与β-磷酸三钙和松质骨髓植入联合应用于犬下颌骨节段性缺损的修复,通过X线片、大体标本和组织学切片对下颌骨节段性缺损的个体化再生修复效果进行观察。结果:犬下颌骨解剖形态恢复十分理想,组织学和X线摄影观察显示钛网内具有新骨形成,新生骨在3个月时已十分明显和成熟。结论:将计算机辅助技术与骨再生材料联合应用,可望通过骨再生途径实现下颌骨节段性缺损的个体化修复重建。Objective： Animal study to provide data for clinical transition of computer aided individualized reconstruction of segmental mandible defect. Methods： Individualized three-dimensional titanium mesh implant was designed by CAD/CAM and used to reconstruct mandibular segmental defect of dogs combined with bone marrow and beta-tricalcium phosphate transplantations. Bone reconstruction results were assessed by radiography and histologic examination. Results： The anatomy mandible morphology was ideally reconstructed. New bone formation could be seen both by the radiographic and the histological examination at the third month. Conclusion： CAD/CAM is a basic tool in individualized reconstruction of mandibular segmental defect. By using mandibular individualized three-dimensional titanium mesh implant and bone regeneration material, individualized reconstruction of mandibular segmental defect by osseoregeneration may be possible.

关 键 词：下颌骨节段性缺损 修复 个体化 骨再生 

分 类 号：R782[医药卫生—口腔医学]