兔肝VX2移植瘤介入性热化疗方法的实验研究  

Experimental study of interventional infusion thermochemotherapy in rabbit liver VX2 tumor

作　　者：刘毅勇[1] 王执民[2] 曹玮[2] 张洪新[2] 李文献[2] 秦向阳[2] 

机构地区：[1]呼和浩特 中国人民解放军第二五三医院放射科,010050 [2]第四军医大学唐都医院介入放射科

出　　处：《介入放射学杂志》2006年第12期746-749,共4页Journal of Interventional Radiology

摘　　要：目的研究2种经动脉热灌注化疗方法对兔肝VX2移植瘤的热化协同效率。方法30只新西兰大白兔建立肝VX2肿瘤模型。经股动脉插管,导管头置于兔肝动脉,DSA证实肿瘤供血动脉后,分3组(每组10只),分别给予常温100 ml盐水+阿霉素(ADM)灌注、60℃热生理盐水100 ml+阿霉素连续灌注、60℃热生理盐水100 ml+阿霉素间歇灌注。灌注过程中,测量60℃热灌注组肿瘤组织内43～45℃持续时间,灌注后即时检测各组肿瘤组织内阿霉素浓度。结果阿霉素浓度：60℃间歇灌注组为(17.622±1.368)μg/ml,60℃连续灌注组为(12.013±2.237)μg/ml,常温灌注组为(11.519±1.225)μg/ml。60℃间歇灌注组与60℃连续灌注组比P＜0.05,60℃连续灌注组与常温灌注组比P＞0.05；43～45℃持续时间：60℃间歇性灌注组为(11.3±3.3)min,60℃连续灌注组为(4.1±2.7)min,60℃间歇灌注组比60℃连续灌注组高近3倍。60℃2组兔的呼吸、心率、体温变化无明显差异。结论经动脉间歇热灌注化疗方法是一种更有效的介入热化疗方法。Objective Effectiveness of two kinds of thermochemotherapy infusion from intraarterial approach were studied in the grafted liver VX2 tumors of rabbit. Methods VX2 tumor model was established in 30 Newzland rabbit＇s livers. Percutaneous transfemoral hepatic arterial catheterization with fixation of the cathether tip inside the feeding vessel was carried out under DSA guidance. All 30 rabbits were divided into three groups （n = 10 in each group）, normal temperature 100 ml saline ＋ Adriamycin（ADM） infusion（group 1）,60℃100 ml saline ＋ ADM continuous perfusion （group 2） and 60℃100 ml saline ＋ ADM intermittent perfusion（group 3）. After the perfusion, the lasting time periods of 43 - 45℃ for tumor tissue of group 2 and 3 together with the concentrations of ADM within tumor＇s tissue were measured. Results Concentrations of ADM were shown as（12.013 ± 2.237）μg/ml, （17.622 ± 1.368）μg/ml, and（11.519 ± 1.225）μ/ml for group 2, group 3 and group 1 respectively. 60℃ intermittent perfusion vs 60℃ continuous perfusion showed P 〈 0.05, 60℃ continuous pefusion vs normal temperature perfusion also showed P 〉 0.05. 43 - 45℃ period lasting time （min） for 60℃ continuous pefusion vs 60℃ intermittent pefusion were （4.1 ± 2.7）min and （11.3 ±3.3）min respectively, the latter was three times more than the former. There were no differences shown betwen the temperature, respiration and heart rate of group 2 and group 3. Conclusion Intermittent intraarterial perfusion thermochemotherapy is a more effective interventional management among all thermochemotherapies.

关 键 词：间歇性灌注 热化疗 经动脉 VX2 肝脏 

分 类 号：R735.7[医药卫生—肿瘤]