E_(838)对小鼠移植瘤S180放疗增敏的实验研究  

The study of the E_(838) effect on the augment of radiation treatment in mouse inoculated S180 strain.

作　　者：王月英[1] 张良安[1] 王汝勤[1] 王育忠[2] 吴红英[1] 穆传杰[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所,天津300192 [2]天津实验动物中心

出　　处：《中国辐射卫生》2006年第4期388-389,共2页Chinese Journal of Radiological Health

基　　金：天津市自然科学重点基金项目(043802411)

摘　　要：目的观察E838的体内抗肿瘤活性,探讨其体内抑瘤作用的机制。方法取E838三个剂量对小鼠S180癌细胞实体瘤模型,进行体内抑瘤及合用137Csγ射线放射增效实验,测定肿瘤生长曲线、骨髓有核细胞(BMNC)数及脾脏、胸腺重量的变化,计算肿瘤生长抑制率。结果E838低、中、高三个剂量对小鼠S180的抑瘤率分别为49.52%、54.81%、53.85%,合用1Gy137Csγ射线抑瘤率分别为52.12%、59.62%、59.62%,其成瘤时间晚于对照组,肿瘤生长速度明显减慢,BMNC数均高于对照组,有统计学意义。结论E838对小鼠S180肿瘤的生长有明显的抑制作用,同时具有放射增敏效应。Objective To observe E838＇s activity of reatraining turmor growth in mouse and discuss the relative mechanism. Methods We used three different doses of E838 to restrain turmor growth in S180 mouse in one team and the other used Csγtogether. Results In one team , the percent of the E938 （dose： low to high）restraining turmor growth is respectively 49.52 %, 54.81% ,53. 85%, in the other is respectively 52. 12% ,59.62% ,59.62% .Not only the tunnor growth of the latter team is slow but the amount of BMNC is high Conclusion E838 can obviously restrain the turmor growth in s180 mouse and has the radiation augment effect.

关 键 词：E838 抗癌药物 S150 癌细胞 放射增敏作用 

分 类 号：R730.58[医药卫生—肿瘤]