胰腺癌组织中肿瘤生长因子-α和表皮生长因子受体的表达与胰周神经侵犯的相关性研究  

Expressions of TGF-α,EGFR in pancreatic carcinoma and their relationship with nervous infiltrative metastasis

作　　者：田韧[1] 龚涌灵[1] 杨劲松[1] 端木忠[1] 张保国[1] 

机构地区：[1]南京医科大学附属第一医院肿瘤科,江苏南京210006

出　　处：《医学研究生学报》2006年第12期1105-1106,1109,共3页Journal of Medical Postgraduates

摘　　要：目的:探讨胰腺癌组织中肿瘤生长因子-α(TGF-α)、表皮生长因子受体(EGFR)表达与胰腺癌胰周神经浸润转移关系。方法:用免疫组织化学方法检测62例胰腺癌组织及其对应癌旁组织中TGFα-、EGFR表达水平。结果:EGFR表达水平与胰腺癌神经浸润转移相关(P<0.05)。胰腺癌中有神经浸润转移者TGF-α/EGFR共同表达为24例(63.16%),无神经浸润转移者共同表达为4例,两者差异具有显著性意义(P<0.05)。结论:EGFR的过度表达及TGF-α/EGFR自分泌环可能在胰腺癌神经浸润转移中起着重要作用。Objective：To study the expressions of TGF-α and EGFR in pancreatic carcinoma. Methods：Expressions of TGF-α and EGFR in 62 tissue samples of pancreatic carcinoma are investigated immunohistochemicatty. Results：The expressions of EGFR in pancreatic carcinoma correlated with nervous infiltrative metastasis （P 〈 0.05 ）. Fourteen of all patient tissue samples under investigation show both TGF-α and EGFR positive. Conclusion ：The over-expression of EGFR may be the indicator of nervous infiltration and the co-expression of TGF-α and EGFR may play an important role in nervous infiltration of pancreatic carcinoma.

关 键 词：胰腺癌 神经浸润转移 肿瘤生长因子-α 表皮生长因子受体 免疫组织化学 

分 类 号：R735.9[医药卫生—肿瘤]