细胞色素P450(CYP450)遗传多态性研究进展  

Progress of research on genetic polymorphism of CYP450s

作　　者：成碟[1] 徐为人[2] 刘昌孝[2] 

机构地区：[1]天津大学化工学院制药工程系,天津300072 [2]天津药物研究院药代动力学和药效动力学省部共建国家重点实验室,天津300193

出　　处：《中国药理学通报》2006年第12期1409-1414,共6页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展规划(973规划)资助项目(No2004BC518902)

摘　　要：近年来对CYP450基因型和表型相关性的研究越来越受到重视,从临床合理用药方面来说,人们希望利用基因型分析来了解个体中药物代谢酶的活性,期望既能提高药物治疗水平同时又降低不良反应的发生;从新药研发角度来说,研究药物的代谢酶CYP450的功能能够指导新药的设计、筛选及优化。该文通过查阅国内外相关文献综述了近年来关于CYP450遗传多态性研究的进展,分别介绍了CYP2C19、CYP2C9、CYP3A4、CYP2D6、CYP1A2和CYP2E1这6种主要的药物代谢酶。研究CYP450对新药设计、筛选、评价及优化有重要意义。In recent years, correlation between genotype and phenotype of CYP450s is gradually paid attention. In the region of clinical rational use of drugs, we hope to know everyone＇s activity of CYP450s respectively by genotype analysis. Then we can not only improve therapeutical effect of drugs but also reduce their adverse reactions. In the region of new drug research and development, study of function of CYP450s can guide design, screening and optimization of new drugs. This paper summarized research development of genetic polymorphism of CYP450s in recent years, and introduced six main drug-metabolizing enzymes respectively; they are CYP2C19, CYP2C9, CYP3A4, CYP2D6, CYP1A2 and CYP2E1. Research on genetic polymorphism of CYP450s is significant to drug design, screening, evaluation and optimization.

关 键 词：细胞色素P450 CYP450 遗传多态性 CYP2C19 CYP2C9 CYP3A4 CYP2D6 CYP1A2 CYP2E1 

分 类 号：R-05[医药卫生] R345.99