CYP2A6酶活性调节机制的研究进展  

Research about the activity of CYP2A6 that related to regulative mechanism

作　　者：陈尧[1] 周宏灏[1] 

机构地区：[1]中南大学临床药理研究所,湖南长沙410078

出　　处：《中国药理学通报》2006年第12期1415-1418,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30572226)

摘　　要：CYP2A6是一个在药理和毒理学上均占有重要地位的代谢酶,香豆素和尼古丁主要由它介导转换,并与吸烟疾病密切相关;而核不均一核糖核蛋白A1(hnRNPA1)是一个在转录后水平上发挥重要调节作用的蛋白,对于某些特异基因,转录后调节影响占有重要的地位。CYP2A6酶活性与hnRNPA1关系的研究是近几年来受到学者关注的,该文试图阐述转录后水平上hnRNPA1对CYP2A6活性的调节影响,更好地掌握CYP2A6活性变化规律,对于指导临床用药及烟瘾戒断治疗有重要的意义。CYP2A6 is an important drug metabolic enzyme that plays a central role in pharmacology and toxicology. Coumarin and nicodine are mainly metabolized by it. CYP2A6 also have a close connection with diseases that related to smoking. While hnRNP A1 is a protein that shows an important regulative action on some specific genes at post-transcription level. Recently, researchers are paying more and more attention to the relationship between the activity of CYP2A6 and the expression of hnRNPA1. In order to master the change rule of CYP2A6 activity, we try to explain the regulative effect on CYP2A6 by hnRNP A1 at post-transcription level, which will bring an important effect on guiding clinical medicine treatments and smoking addictive therapy.

关 键 词：CYP2A6 HNRNP A1 转录后调节 尼古丁 

分 类 号：R-05[医药卫生] R163