ET-1、ETA-R在宫颈癌中的表达与HPV感染的关系  

The relationship between endothelin-1 endothelin A receptor expressions and HPV infections in cervical carcinoma.

作　　者：牛小红[1] 杨永秀[1] 董金翰 

机构地区：[1]兰州大学第一医院妇产科,兰州730000 [2]上海长宁区妇幼保健医院

出　　处：《现代妇产科进展》2006年第11期838-840,I0001,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨ET-1及ETA-R表达在宫颈癌发生中的病理生理作用及其与HPV感染的关系。方法:应用免疫组化SP法对68例宫颈癌组织及10例非癌变宫颈组织进行ET-1、ETA-R、HPV16/18E6免疫特异性染色。结果:(1)HPV16/18E6阳性率在宫颈癌中占82.3%,对照组宫颈组织中占20%,二组HPV16/18E6表达有统计学差异(P<0.001);(2)HPV阳性宫颈癌组织ET-1、ETA-R阳性表达率100%,而HPV阴性宫颈癌组织ET-1、ETA-R阳性表达率0%,对照组ET-1、ETA-R阳性表达率20%,3组ET-1、ETA-R表达有统计学差异(P<0.001);(3)ET-1、ETA-R在宫颈癌中的表达均与临床分期、病理分级、组织学类型无关(P>0.05)。结论:HPV是否感染与功能性ET-1/ETA-R自分泌环有关,而ET-1/ETA-R自分泌环是肿瘤生长的驱动器,其功能上调可能是HPV感染子宫颈上皮细胞引起宫颈癌发生的一种新的调控机制。Objective：To investigate whether expressions of Endothelin-1 and Endothelin A receptor in cervical carcinoma are associated with HPV infection in cervical cancer. Method：Immunohistochemical staining was carried out on 68 cervical carcinoma cases and 10 non-canceration cervical tissue by using antibodies against ET-1 and ETA-R and HPV16 / 18E6. Results： （1）The expression of HPV16/18E6 in cervical carcinoma was higher than that in control group（P 〈 0. 001 ）. （2） All HPV-positive cervical carcinoma cells expressed ET-1 and ETA-R,whereas HPV-negative cervical carcinoma cells did not express ET-1 and ETA-R （P 〈0. 001 ）. （3） There was no relationship between the expression of ET-1 and ETA-R and grade, stage or histological types（ P 〉 0.05 ）. Conclusions：The presence of HPV infection is associated with an active ET-1/ETA-R autocrine loop. ET-1/ETA-R autocrine loop is one of the drives of tumor growth. The up-regulation of ET-1/ETA-R autocrine loop might provide a selective growth advantage for HPV-associated cervical carcinoma.

关 键 词：宫颈肿瘤 免疫组织化学 内皮缩血管肽1 内皮缩血管肽A受体 人乳头状瘤病毒16/18型 E6基因 

分 类 号：R737.33[医药卫生—肿瘤]