血清TPSA、F/TPSA在前列腺癌诊断中的临床意义  

The clinical value of serum total PAS and the ratio of free to total PSA in diagnosis prostatic carcinoma

作　　者：葛波[1] 杨燕伟[1] 蒋雷鸣[1] 高漓[1] 

机构地区：[1]桂林医学院附属医院泌尿外科,广西桂林541001

出　　处：《华夏医学》2006年第6期1075-1077,共3页Acta Medicinae Sinica

摘　　要：目的探讨血清总前列腺特异抗原(TPSA)、游离前列腺特异抗原(FPSA)检测及其比值(F/T)在前列腺癌诊断中的临床意义。方法用酶联免疫方法检测在我院住院或门诊治疗的137例前列腺癌和前列腺增生患者的TPSA和F/TPSA比值。结果总体比较两组间TPSA及F/TPSA均有统计学意义,在诊断灰区(4ng/ml<TPSA≤10ng/ml)外高值区,TPSA、F/TPSA在两组间的差别均有统计学意义(P<0.01);在诊断灰区的TPSA两组间的差别无统计学意义(P>0.05),而F/T在两组间的差别有统计学意义(P<0.05),在灰区外低值区,TPSA、F/TPSA在两组间的差别均无统计学意义(P>0.05)。结论血清TPSA为前列腺癌的标志物,仍是前列腺癌的主要诊断手段,但F/TPSA值检测能更准确地鉴别位于灰区的前列腺病变性质,在灰区的诊断有重要的意义。Objective：To investigate the clinical value of serum total PAS and the ratio of free to total PSA（F/T） in differential diagnosis benign prostate hyperplasia （BPH）and prostatic carcinoma （PCa）. Methods：Serum FPSA and TPSA were measured in 137 patients with prostate carcimoma（PCa） and benign prostate hyperplasia（BPH） by using enzyne linked immunosorbent assay and the ratio of FPSA/TPSA was calculated. Results ： The comparison of TPSA and F/TPSA between total of the two kinds of diseases showed statistical significance. Total PSA, F/TPSA were significantly discriminated between PCa and BPH （P〈0. 01） when the assessed value were much higher beyond gray zone. But the assesses value were within the gray zone,only the comparison of F/TPSA showed statistical significance （P〈 0. 05）. The assessed value were in lower value range beyond the gray zone, TPSA, F/TPSA could not specifically differentiate between the two conditions （both were P〉0. 05）. Conclusion： Serum TPSA is a marker, the determination of TPSA is the important method in diagnosis of prostatic carcinoma,But within gray zone,F/TPSA has more important role in discriminating the PCa and BPH.

关 键 词：前列腺肿瘤 前列腺增生 前列腺特异抗原 

分 类 号：R737.25[医药卫生—肿瘤]