氯丙嗪、利培酮治疗精神分裂症致糖耐量变化的研究  

Study on Influence of the Short-term Therapy by Chlorpromazine or Risperidal on 2hPG

作　　者：王涛[1] 瞿正万[2] 傅伟忠[3] 王豪[1] 

机构地区：[1]上海市浦东新区精神卫生中心门诊部,200122 [2]上海市浦东新区精神卫生中心业务部,200122 [3]上海市浦东新区精神卫生中心防治科,200122

出　　处：《齐齐哈尔医学院学报》2006年第12期1417-1419,共3页Journal of Qiqihar Medical University

摘　　要：目的研究利培酮和氯丙嗪短期治疗精神分裂症患者2小时糖耐量变化特点。方法随机选择198例未曾治疗或停药3个月以上的精神分裂症患者,分别接受利培酮、氯丙嗪治疗。在入院时,治疗1、2、3、6个月后检测2hPG。结果氯丙嗪治疗3月后2hPG值明显增高,利培酮组增高不明显;≥40岁组2hPG明显高于<40岁组;同年龄组比较,治疗6个月,20岁以上各组2hPG浓度明显高于治疗前。结论氯丙嗪比利培酮更易引起2hPG值增高,治疗3个月检测2hPG值有助于判断精神病患者伴发糖尿病的风险。Objective To study the 2hPG about antipsyehotie in the short--term therapy. Methods 198 inpatients with Schizophrenia were untreated or stopped antipsychotics beyond 3 months, were randomly chosen. They were treated separately by ehlorpromazine or risperidal and detected the 2hPG, before treatment,after one, two, three, and six months treatment. Results The 2hPG after three months in chlorpromazine group obviously raised compared with previous treatment,huT risperidal group was not apparent. ≥40 years old group 2hPG was obviously higher than 〈40 years old group. To compare the same age group,above 20 age group,s 2hPG obviously raised compared with previous treatment. Conclusions Chlorpromazine was easier than rlsperldal to make the 2hPG raised. To detect 2hPG in the third month treatment is available to adjust the risk of concomitant diabetes.

关 键 词：糖耐量 精神分裂症 抗精神病药物 

分 类 号：R749.3[医药卫生—神经病学与精神病学]