人乳头状瘤病毒16/18感染与喉鳞状细胞癌关系  

Human Papillomavirus16/18 Subgroup Infection in Laryngeal Squamous Cell Carcinomas

作　　者：陈志凌[1] 吴正虎[2] 郭星[3] 吴祖良[4] 

机构地区：[1]浙江省中医药大学附属第二医院杭州市中医院耳鼻咽喉科,310007 [2]浙江省杭州市第二人民医院耳鼻咽喉科 [3]中国医科大学附属第一医院耳鼻咽喉科 [4]浙江省人民医院耳鼻咽喉科

出　　处：《医学研究杂志》2006年第11期28-30,共3页Journal of Medical Research

基　　金：浙江省杭州市医药卫生科技计划重点资助项目(编号2004A011)

摘　　要：目的研究喉鳞癌组织中人乳头状瘤病毒(humanpapillomavirus,HPV)16/18亚型的感染情况并进行临床分析。方法应用原位杂交法分别检测39例喉鳞癌组织,10例声带息肉组织中HPV16/18亚型的感染情况,并分析喉鳞癌组织中HPV16/18阳性感染与肿瘤各项临床病理参数的关系。结果39例喉鳞癌组织中HPV16/18阳性率为48.7%(19/39)。10例声带息肉组织中均未见HPV16/18感染(0/10)。HPV16/18在喉鳞癌组织与声带息肉组织中的表达差异经χ2检验有统计学意义。喉鳞癌组织中HPV16/18感染与癌组织的的组织学分级、临床分期、淋巴结转移间经Fisher′s精确概率法χ2检验均未见相关性。结论喉鳞癌的发生与HPV16/18感染相关。Objective To investigate the correlation between human papillomavirus（HPV） 16/18 subgroup infection and laryngeal squamous cell carcinoma（LSCC）. Methods The infection of HPV16/18 in 39 laryngeal carcinoma specimens and 10 vocal cord polyp specimens were detected by in situ hybridization. Results The positive rate of HPV16/18 expression in 39 laryngeal carcinoma specimens was 48.7% （19/39）. The positive rate of HPV16/18 subgroup expression in 10 vocal cord polyps was 0（0/10）. Statistical test showed that HPV16/18 subgroup infection was significantly higher in LSCC than that in vocal cord polyps. No statistically association was observed among the frequency of HPV16/18 subgroup infection and TNM stages, degree of differentiation or lymph nodes metastases. Conclusions HPV 16/18 subgroup infection is associated with he pathogenesis of LSCC.

关 键 词：喉肿瘤 癌 鳞状细胞 乳头状瘤病毒 人 原位杂交 

分 类 号：R737.33[医药卫生—肿瘤]