端粒酶检测在良恶性胸腔积液鉴别诊断中的应用价值  

Application value of telomerase examination for malignant pleural effusion

作　　者：单彬彬[1] 韩福才[2] 

机构地区：[1]山西医科大学第二医院,太原030001 [2]山西省肿瘤医院呼吸科

出　　处：《肿瘤研究与临床》2006年第12期857-859,共3页Cancer Research and Clinic

摘　　要：端粒酶是一种能以自带RNA为模板,反转录合成端粒DNA加于染色体末端的核糖核酸蛋白酶,作用是维持染色体稳定,使细胞具有永生化特性。胸腔积液可由多种疾病引起,与肿瘤因素有关者占30%￣60%。作为目前最具特异性和普遍性的恶性肿瘤标志物,检测胸腔积液中端粒酶的活性,对早期发现肿瘤,具有重要意义。Telomerase is a ribonucleoprotein that synthesizes telomeric DNA onto chromosomal ends using an component as a template. Extension of telomeric repeats by telomerase prevents telomere shortening with cell divisions and contributes to chromosomal stability, possibly leading to immortalization of the cells. pleural effusion is cause by many kinds of diseases. 30 % ～ 60 % malignant pleural effusion is caused by malignant tumor, Telomerase might be a tumor marker for detecting malignancy tumor. The detection of telomerase activity is significant for earlier diagnosis.

关 键 词：端粒酶 恶性胸腔积液 诊断 

分 类 号：R730.4[医药卫生—肿瘤] R561[医药卫生—临床医学]