食管癌中Skp2和p27^(kipl)蛋白表达及其临床意义  

Expression and clinical significance of Skp2 and p27^(kipl) in esophageal squamous cell carcinoma

作　　者：王斌[1] 宋军[1] 徐少勇[1] 邓长生[2] 

机构地区：[1]郧阳医学院附属人民医院消化科,湖北十堰442000 [2]武汉大学中南医院消化科

出　　处：《中国肿瘤临床与康复》2006年第6期488-490,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨细胞S相激酶相关蛋白(Skp2)、p27^(kipl)蛋白表达与食管癌的关系。方法用免疫组化S-P法检测58例食管癌中Skp2、p27^(kipl)蛋白的表达。结果58例食管癌组织中Skp2、p27^(kipl)蛋白阳性表达率分别为32.76%和58.62%;二者的阳性表达率均与食管癌患者的年龄、性别、肿瘤部位无关(P>0.05)。Skp2阳性表达率随肿瘤分化程度降低而升高,p27^(kipl)阳性表达率随肿瘤分化程度降低、浸润深度加深、恶性程度增加而逐渐降低(P<0.05)。Skp2与p27^(kipl)表达呈显著负相关(P<0.01)。结论在管癌中Skp2主要的泛素化降解靶物质是p27^(kipl),它通过影响p27^(kipl)降解进而影响肿瘤的进展,导致不良预后。Objective To investigate the clinical significance of p27^kipl and S-phase kinase-associated protein 2 （Skp2） expression in human esophageal squamous cell carcinoma（SCC）. Methods The expression of p27^kipl and Skp2 was determined by SP method in 58 specimens of esophageal SCC. Results The positive rates of p27^kipl and Skp2 expression were 32.8% and 58.6%, respectively. The positive rates of both p27^kipland Skp2 expression were not associated with the patients＇ age, sex and tumor location （ P 〉 0.05）. The positive rate of Skp2 expression increased with decreasing differentiation degree of esophageal SCC,while the positive rate of p27^kipl expression in esophageal SCC decreased with the poor differentiation,deep invasion and increase in malignant grade （ P 〈 0.05）. There was a negative correlation between the p27^kipl and Skp2 expression（P 〈 0.01 ）. Conclusion The target substrate of Skp2 in esophageal SCC is mainly p27^kipl ,and Skp2-indueed degradation of p27^kipl may influence tumor progression and lead to a poor prognosis.

关 键 词：食管肿瘤 SKP2 P27^KIPL 免疫组化 

分 类 号：R735.1[医药卫生—肿瘤] R730.45[医药卫生—临床医学]