脑卒中后抑郁患者事件相关电位P300的临床研究  

The Clinical Study of Event-related Potential P300 for Post-stroke Depression

作　　者：谢瑛[1] 李立新[1] 

机构地区：[1]北京电力医院,北京100073

出　　处：《实用医技杂志》2006年第23期4122-4124,共3页Journal of Practical Medical Techniques

摘　　要：目的:探讨P300检测对于评定脑卒中后合并抑郁患者认知功能障碍的价值。方法:用汉密切尔抑郁量表(HAMD)测试80例急性脑卒中患者,并将其分为抑郁组和非抑郁组,并设正常对照组60例,均经P300及HAMD检查。结果:抑郁组与非抑郁组,非抑郁组与正常对照组比较,P300潜伏期及波幅,HRSD评分差异均有显著性(P<0.01)。卒中后抑郁组患者P300潜伏期、波幅与其HAMD评分呈无显著相关性(P>0.05)。结论:P300检测可作为评定脑卒中合并抑郁患者认知功能的可靠手段。Objective To explore the clinical value of P300 in the evaluation of cognition for post-stroke depression. Mothods 80 acute stroke patients were assessed by Hamilton , and then were divided into two groups ： the depressive group and the undepressive group, , healthy control groups were selected. All objects were measured by P300 and the HAMD. Rosults There were significant differences in P300 peak latency , amplitude and the HAMD score between the patients pf depression or undepression and the controls respectively （P 〈 0.01 ）. In the group of post-stroke depression , the HAMD score have no significant correlation with the P300 peak latency and amplitude （P 〉 0.05）. Conclusion The results suggest that the P300 can be the reliable evaluative means of cognition for the post-stroke depression.

关 键 词：事件相关电位P300 脑卒中 抑郁 认知 

分 类 号：R749.1[医药卫生—神经病学与精神病学]