便秘的肛门直肠动力和血浆活性肠肽变化的研究  

Changes of anorectal motility and serum vasoactive intestinal polypeptide in patients with chronic constipation

作　　者：张义侠[1] 林红[1] 刘峥艳[1] 傅宝玉[1] 

机构地区：[1]中国医科大学附属第一医院消化内科,辽宁沈阳110001

出　　处：《中国医科大学学报》2006年第2期183-184,共2页Journal of China Medical University

摘　　要：目的:观察慢性便秘各型的肛门直肠动力学和感觉功能的变化,测定血浆中血管活性肠肽(VIP)的变化。方法:用肛门直肠测压的方法测定直肠肛门动力及感觉功能;用放免法检测血浆中VIP的含量。结果:传输时间正常型便秘组的肛管静息压降低(P<0.05);传输时间延长型便秘组肛管静息压降低,直肠最大耐受容积增大(P<0.05);便秘各型血浆中VIP均升高(P<0.05)。结论:不同类型的便秘存在不同的结肠、肛门直肠动力学改变和内脏感觉异常。血浆VIP水平升高在慢性便秘的发病机制中可能起作用。Objective： To investigated the changes of anorectal motility and sensory function in patients with different types of chronic constipation. Methods：Anorectal manometry was performed to determine the changes of anorectal motility and sensory function. The content of serum vasoactive intestinal peptide （VIP） was detected. Results ：The anal resting pressure in patients with normal and delayed transit time was significantly lower than that in normal controls （ P 〈 0.05）. The rectal maximum tolerable vohune in patients with delayed transit time was significantly larger than that in normal controls （ P 〈 0.05 ）. The serum VIP in each type of chronic constipation was significantly higher than that in normal controls （ P 〈 0.05 ）. Conclusion： The anarectal motility and rectal sensation vary in different types of chronic constipation. The elevated level of serum VIP may be involved in the pathogenesis of chronic constipation.

关 键 词：便秘 姑肠传输时间 肛门直肠动力 血管活性肠肽 

分 类 号：R574.62[医药卫生—消化系统]