P53,C-erbB2,rasP21,nm23-H1基因表达与大肠癌淋巴结转移的关系  

P53,C-erbB2,rasP21,nm23-H1's expression and lymphatic metastasis in human colorectal carcinoma

作　　者：吕炳蓉[1] 檀碧波[1] 韩杰[1] 吕柏楠[1] 石晓明[1] 吴胜春[1] 

机构地区：[1]河北省人民医院普外二科,石家庄市050051

出　　处：《河北医药》2006年第12期1136-1137,共2页Hebei Medical Journal

基　　金：河北省科技厅指导性科研项目(编号:20042761570)

摘　　要：目的探讨大肠癌组织中癌基因和抑癌基因在大肠癌淋巴转移中的作用。方法利用免疫组化方法(SP法)检测大肠癌组织中癌基因和抑癌基因。结果224例大肠癌患者中,淋巴结的转移率随分化程度降低而增高;随癌组织浸润深度增加,淋巴结的转移率明显提高;淋巴结转移的阳性率还随癌基因及其产物P53、C-erbB2、rasP21的出现而增加,而随nm23-H1的表达而降低。结论癌基因、抑癌基因的检测将有助于研究肿瘤淋巴转移的原因和机制,并对淋巴转移进行预测。Objective To investigate the effect of P53, rasP21, nm23 H1 genes on lymphatic metasasis in human colorectal carcinoma.Methods The expression of P53, rasP21,C-erbB2 and nm23 H1 in human colorectal carcinoma were studied immunohistochemically （S-P）. Results Of 224 cases of colorectal carcinoma the lymphatic metastasis were significantly higher in the primary colorectal carcinomas with tissue infiltration to subserosa （ P 〈 0.01）.The lymphatic metastasis were significantly higher in P53, C-erbB2, rasP21 positive expression （ P 〈 0.05） and negative expression of nm23-H1 （ P 〈0.05）.Conclusion The expression of P53,C-erbB2, rasP21 and nm23- H1 were associated lymphatic metastasis in human colorectal carcinoma. These findings suggest a potential role of P53, C - erbB2, rasP21 and nm23-H1 in lymphatic metastasis in human colorectal carcinoma angiogenesis.

关 键 词：大肠癌 P53 C-ERBB2 ras P21 NM23-H1 

分 类 号：R737.31[医药卫生—肿瘤]