曲安奈德与透明质酸钠治疗颞下颌关节骨关节病的动物实验研究  

An animal experimental study of intra-articular injection of triamcinolone acetonide and sodium hyaluronate for the treatment of temporomandibular joint osteoarthrosis

作　　者：来庆国[1] 宋代辉[2] 谢坤[3] 金延武[3] 袁奎封[1] 

机构地区：[1]山东大学第二医院口腔科,山东济南250033 [2]山东大学口腔医院口腔外科,山东济南250012 [3]山东大学第二医院麻醉科,山东济南250033

出　　处：《山东大学学报（医学版）》2006年第12期1248-1252,共5页Journal of Shandong University:Health Sciences

摘　　要：目的:评价曲安奈德和透明质酸钠对山羊颞下颌关节骨关节病的治疗效果。方法:对9只山羊的双侧颞下颌关节上腔一次性注射胶原酶而诱导骨关节病变后,分三组,每组3只。对照组中3只山羊关节上腔注射1 ml生理盐水,两治疗组关节上腔分别注射1 ml曲安奈德和1 ml透明质酸钠,处死后对关节进行光镜和扫描电镜观察。结果:在光镜下观察,与对照组的典型骨关节病病理特征比较,透明质酸钠治疗组表现出较轻的骨关节病病理变化,而曲安奈德治疗组中则表现出严重的骨关节病变化。扫描电镜与光镜下观察结果一致。结论:通过3个月的观察和研究结果表明,用曲安奈德关节上腔封闭能加重骨关节病病理变化,而用透明质酸钠关节上腔封闭能抑制颞下颌关节骨关节病的发展进程。Objective： To investigate the efficacy of triamcinolone acetonide and sodium hyaluronate for treatment of temporomandibular joint （TMJ） osteoarthrosis of goats. Methods： The upper compartments of both joints of 9 goats were injected with collagenase to induce osteoarthrosis. The 9 goats were devided into 3 groups, 3 goats per group. The upper compartments of both TMJs in three goats in control group were injected with lml physiological saline and in the two treatment groups were injected with lml triamcinolone acetonide and sodium hyaluronate, respectively. The TMJs of goats were examined under light microscopy and scanning electron microscopy after being sacrificed, and were scored in a subjective manner following the standard criteria which was a modification of the method of Mankin, et al and Yoshimi, et al. Results： Under light microscopy, the treatment group with sodium hyaluronat showed a light ostcoarthtotic changes and the treatment group with triamcinolone acetonide showed more severe ostcoarthtotic changes when comparing with the control group. Result under scanning electron microscopy accorded with the result under microscopy. Conclusion： On the basis of 3-month following-up, intra-articular injection of triamcinolone acetonide will aggravate the esteoarthrotic changes while intra-articular injection of sodium hyalm＇onate seems to curb the development of temporomandibular joint osteoarthrosis.

关 键 词：颞下颌关节 骨关节病 曲安奈德 透明质酸 

分 类 号：R782.6[医药卫生—口腔医学] R-332[医药卫生—临床医学]