以运动障碍起病的癌性周围神经病  

Paraneoplastie Peripheral Neuropathy with Onset of Weakness

作　　者：王宪玲[1] 贾建平[1] 

机构地区：[1]首都医科大学宣武医院神经内科,100053

出　　处：《脑与神经疾病杂志》2006年第6期404-406,共3页Journal of Brain and Nervous Diseases

摘　　要：目的:对以运动障碍起病的癌性周围神经病进行临床分析,提高早期诊断率。方法:收集宣武医院2000年至今临床诊断的以运动障碍起病的癌性周围神经病,对其临床特点,辅助检查结果进行分析。结果:共收集病例9例,均以运动障碍就诊,平均发病年龄60.67±14.06岁,男性6例,女性3例,2例为发现肿瘤后出现临床症状,7例为先出现神经系统症状后进一步检查发现肿瘤,其中发现转移瘤2例。发病多为慢性或亚急性起病,进行性加重,治疗效果欠佳。结论:对中年以上以运动障碍起病的亚急性或慢性周围神经病,用常见周围神经病原因不能解释时应进行全面检查以发现潜在的肿瘤。Objective： To improve the early diagnostic accuracy of Paraneoplastic peripheral neuropathy. Methods： the patients with paraneoplastic peripheral neuropathy with onset of weakness were included, and their clinical features and examinations were analyzed. Results： 9 cases with predominant weakness of limbs were included , with mean age 60.67±14.06. CSF examination showed normal or slightly increased protein level. Electrophysiological examination implied a primary damage restricted to the peripheral nerve. Conclusion： Subacute and chronic weakness and sensory loss can be important indicators of neurologic disorders associated with malignancy. Tests should be done to diagnose a presumably occult turnout when the paraneoplastic peripheral neuropathy is suspected in a patient with weakness of limbs.

关 键 词：癌性周围神经病 运动障碍 慢性周围神经病 神经系统症状 检查结果 发病年龄 早期诊断率 进行性加重 

分 类 号：R739.43[医药卫生—肿瘤]