乳腺增生病雌、孕激素受体表达及临床意义  

Clinical siginficance and expression of ER and PR in breast cancer

作　　者：李永茂[1] 安凤玲[2] 田旭阳[1] 高艳君[1] 杜改英[1] 吕文丽[1] 韩煦渊[1] 

机构地区：[1]内蒙古科技大学包头医学院第二附属医院,内蒙古包头014030 [2]内蒙古包头市第四医院病理科,内蒙古包头014030

出　　处：《现代肿瘤医学》2007年第1期35-37,共3页Journal of Modern Oncology

基　　金：内蒙古包头市卫生基金资助项目(编号:BK2004153)

摘　　要：目的:探讨乳腺增生病变组织中雌、孕激素受体表达情况,及其临床意义。方法:将乳腺增生病患者手术切除标本,常规福尔马林固定,石蜡包埋,采用免疫组化S-P法,测定ER、PR表达。结果ER和PR总阳性率74.36%(27/39)和87.18%(34/39),ER、PR同时阳性为66.67%(26/39)。本组不典型增生6例ER和PR阳性率均为100%,其表达强度最强,其次为腺病伴腺瘤形成,最弱为小叶增生。结论:乳腺增生病变组织中ER、PR虽然呈高表达,是三苯氧胺(TAM)治疗的适应症,但仍有25.64%的患者ER呈阴性表达,因此,用TAM治疗乳腺增生病前应检测患者的ER和PR,阳性者可用TAM治疗。Objective： To investigate the expression of estrogen receptor（ER） and progesterone receptor（PR） in breast cancer and the clinical significance. Methods： Detect ER and PR in 39 cases paraffin specimens of females with breast cancer by immunohistochemical staining, Results： The positive rates of ER and PR expression in 39 cases were 74.36% and 87.18% respectively. Both ER and PR positive vate was 66.67%, 6 cases with atipical ductal epithelial hyperplasia were 100% positive . The cases of lobular hyperplasia were the most weak expressed, 3 cases with apocrine metaplasia were positive only for ER. Clondosion： ER and PR are high positive expression with breast cancer, and are indication for ＂cinical treatment of endocrine（TAM） , but 25.64% of cases showed negative. ER and PR should be examnated before using TAM.

关 键 词：乳腺增生病 雌激素受体(ER) 孕激素受体(PR) 

分 类 号：R737.9[医药卫生—肿瘤]