急性脑梗死TOAST病因分型及血清炎性标志物测定的临床意义  

Classification of acute cerebral infarction subtypes according to TOAST criteria and predictive value of plasma inflammation markers

作　　者：王庄[1] 诸金水[1] 刘泉坤[1] 王亚仙[1] 张冰[1] 许贻白[1] 陆惠芬[1] 

机构地区：[1]湖州市中心医院神经内科,313000

出　　处：《浙江医学》2006年第12期967-969,共3页Zhejiang Medical Journal

摘　　要：目的探讨急性脑梗死患者血清炎性标志物水平与颈动脉硬化及脑梗死各亚型的关系。方法检测168例急性脑梗死患者血清高敏C反应蛋白(hsCRP)、金属基质蛋白酶9(MMP9)、白介素6(IL-6)浓度,检查颈动脉彩超,并和对照组进行比较分析;对脑梗死组按TOAST病因分型方法分类后,各亚型与对照组进行比较。结果脑梗死组患者血清hsCRP、MMP9、IL-6水平均明显高于对照组,颈动脉彩超提示的软斑数也明显多于对照组。亚组比较中,除其他原因引起的缺血性卒中(SOE)因例数少未作分析,其他各型均存在多项血清炎性标志物水平异常,其中大动脉粥样硬化性卒中(LAA)及小动脉卒中/腔隙性脑梗死(SAA)三项指标均明显高于对照组,以LAA组增高最显著。结论炎症及炎性血清标志物在脑梗死发生、发展过程中起重要作用,它与LAA、SAA型的发生关系更为密切。Objective To investigate the association of plasma inflammation markers with carotid artery atherescleresis and their correlation with acute cerebral infarction （CI）. Methods The study included 168 cases with CI （CI group） and 50 normal subjects （control group）. In both groups, numbers of carotid plaque were assessed by Doppler Ultrasonography, and the plasma inflammation markers hsCRP, MMPg, IL-6 were measured. The levels of plasma hsCRP, MMP9, IL-6 in the subtypes of CI with those of the control group. Results The levels of plasma hsCRP, MMPg,IL-6 and the numbers of the carotid instable plaque in patients with CI were significantly higher than those in the controls. The levels of the plasma hsCRP, MMPg, IL-6 were much higher in patients with LAA and SAA than those in controls. Conclusion Inflammatory reaction might be a risk factor for CI. The levels of plasma inflammatory markers are high in patients with ischemic cerebrovascular disease particularly for subtypes LAA and SAA.

关 键 词：脑梗死 TOAST分型法 血清炎性标志物 

分 类 号：R743.3[医药卫生—神经病学与精神病学]