低氧诱导因子在非小细胞肺癌中的表达  

Expression of hypoxia inducible factor-1α in non-small cell lung cancer

作　　者：高晓来[1] 周彩存[2] 

机构地区：[1]江苏省苏州市市立医院东区呼吸科,215001 [2]上海肺科医院肿瘤内科

出　　处：《中国现代医药杂志》2006年第12期26-28,共3页Modern Medicine Journal of China

摘　　要：目的探讨低氧诱导因子(HIF-1α)在非小细胞肺癌(NSCLC)中的表达水平及临床意义。方法采用免疫组织化学法检测40例非小细胞肺癌组织和10例正常肺组织中HIF-1α的表达。结果HIF-1α在非小细胞肺癌中的表达率为52.5%(21/40),其中鳞癌中的表达率68%(17/25)高于腺癌的表达率26.7%(4/15()χ2=4.87,P<0.05)。临床分期中Ⅰ￣Ⅱ期HIF-1α阳性表达率为42.3%(11/26),Ⅲ￣Ⅳ期HIF-1α阳性表达率为85.7%(12/14),两者差异具有显著性(χ2=5.35,P<0.05),低分化的表达率71.4%(15/21)高于中高分化的表达率42.3%(11/26()χ2=4.82,P<0.05)。HIF-1α的表达与有无淋巴结转移肿瘤无关(χ2=0.028,P>0.05)。10例正常组织中HIF-1α呈阴性表达。结论HIF-1α在非小细胞肺癌中增强表达与肿瘤的分化、临床分期及病理组织类型有明显关系(P<0.05),而与淋巴结转移无关,认识HIF-1α在肿瘤不同阶段的表达可为抗肿瘤治疗提供新的思路。Objective To study expression level and its clinical significance of hypoxia inducible factor -1α（HIF-1α） in non-small cell lung cancer （NSCLC）. Methods The expression of HIF-1α was detected in 40 human non-small cell lung cancer samples by immunohistochemistry. Results Twenty-one （52.5%）out of 40 human non-small cell lung cancer samples were positive for HIF-1α The expression rate of HIF-1α in squamous cell carcinoma （68%,17/25） was higher than that in adenocarcinoma. （26.7%,4/15）（P〈0.05）.The expression rate of HIF-1α in Ⅲ- Ⅳ stage（85.7%,12/14） was higher than that in Ⅰ- Ⅱ stage （42.3%,11/26） （P〈0.05）. The expression rate of HIF-1α in low-differentiated samples（71.4%,15/21） was higher than that in moderate-to well- differentiated samples （42.3%,11/26） （P〈0.05）. The expression rate of HIF-1α was not related to lymph node status （P〉0.05）. The expression of HIF-1α in 10 case of normal lung tissue was negtive.Conclusion High expression of HIF-1α exists in non-small cell lung cancer,and it may be related to histology and cell differention and TNM stage of tumor.

关 键 词：低氧诱导因子 非小细胞肺癌 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]