富亮氨酸重复超家族成员与脑瘤的研究进展  

Progression of brain tumor and members of leucine-rich repeat superfamily

作　　者：李丹 李桂源[1] 

机构地区：[1]中南大学肿瘤研究所,长沙410078

出　　处：《国际病理科学与临床杂志》2006年第6期466-469,共4页Journal of International Pathology and Clinical Medicine

基　　金：国家重大科学研究计划(2006CB910500);国家自然科学基金重点项目(30330560);湖南省科技厅重大专项(05SK1001-1);湖南省自然科学基金(06JJ20080)

摘　　要：富亮氨酸重复(LRR)超家族成员已达4 000多种,它们在进化上保守、功能多样。许多研究表明,LRR蛋白在神经系统的发育及正常功能的维持中扮演重要角色,与脑瘤的发生发展亦存在一定的联系。LG I1,LR-RC4主要分布于正常脑组织,与脑胶质瘤的恶性程度密切相关,随着胶质瘤恶性程度的增高,其表达逐渐下调甚至缺失。Slitrk,Slit及GAC1等亦参与了脑瘤的发生发展。There are over 4 000 proteins with leucine-rich repeat domain in various organisms from virus to eukaryote, which construct a protein superfamily with evolutional conservatism and functional diversity. LRR proteins play an important role in the development of nervous system, the maintenance of normal function, and the development of brain tumor as well. It was detected that LGII was predominantly expressed in normal neural tissues, especially in brain tissues, and down-regulated gradually with increasing grade of for its activity can malignancy in gliomas. Re-expression of the LGI1 gene in glioma cells that were null greatly reduce their malignant potential. LRRC4 expression was limited to normal brain, however lower or absent expression in majority of brain tumors, especially in gliomas. LRRC4 has the potential to suppress tumorigenesis and cell proliferation of U251MG cells. Other LRR proteins also participate the development of brain tumors, such as Slitrk, Slit and GAC1. There is a close correlation between LRR proteins and brain tumors.

关 键 词：富亮氨酸重复 脑瘤 LRRCA 

分 类 号：R739.4[医药卫生—肿瘤]