氯化镉对大鼠子宫内膜细胞的增殖作用  

Proliferation of Endometrium in Mice Exposed to Cadmium Chloride

作　　者：汤晓阳 付远辉 吴逸明[2] 陈小玉[2] 

机构地区：[1]河南省医疗器械检验所,郑州市450003 [2]郑州大学公共卫生学院劳动卫生教研室,郑州市450052

出　　处：《医药论坛杂志》2006年第23期11-13,共3页Journal of Medical Forum

摘　　要：目的研究氯化镉对去卵巢大鼠子宫内膜细胞的增殖作用。方法将成年雌性大鼠去卵巢后，给予不同剂量的CdClz（0．08mg,／kg、0．40mg／kg和2．00mg／kg）连续3d，观察子宫内膜细胞有丝分裂指数和嗜银染色颗粒数。结果氯化镉中、高荆量组有丝分裂指数分别为0．81％，0．97％，均高于阴性对照组，差异有显著性（P〈0．05）。同时氯化镉高剂量组嗜银染色颗粒数为1．36～1．53，与阴性对照组相比，差异有显著性（P〈0．05）。结论氯化镉能加速细胞的分裂和增殖，因此，推断它在大鼠体内可能具有雌激素样作用。Objective To study the proliferative effect of Cadmium Choride on endometrium in rats. Methods The ovariectomized sexual mature female SD rats were administrated with Cadmium Chloride（0. 08mg/kg,0. 40mg/kg,2. 00mg/kg） for 3 days. The proliferative effects were evaluated by mitotic index（MI） and argyrophilic nucleolar organizer region -associated proteins （Ag -NORs）. Resuits The MI in two groups （ middle and high dose,0. 81% and 0. 97 % ） treated with Cadmium Chloride were higher than that of negative control group, and there were significant difference from that of negative control group （P 〈 0. 05 ） and the means of Ag - NORs （ 1.36 - 1.53 ） in negative control group and high dose groups （ P 〈 0. 05 ）. Conclusion Cadmium Chloride can promote proliferation of endometrial cells in rats, therefore, it is likely to act as an estrogen in vivo.

关 键 词：氯化镉 有丝分裂指数 嗜银染色 雌激素样作用 

分 类 号：R-332[医药卫生]