青岛市成人双生子吸烟饮酒遗传度分析  

Analysis on heritability of cigarette smoking and alcohol drinking in adult twins in Qingdao city

作　　者：宁锋[1] 逄增昌[2] 汪韶洁[2] 任杰[2] 田小草[1] 

机构地区：[1]青岛大学医学院营养研究所,青岛266021 [2]青岛市疾病预防控制中心

出　　处：《中国公共卫生》2007年第1期67-68,共2页Chinese Journal of Public Health

基　　金：中华医学基金(CMB)资助项目(01-746)

摘　　要：目的分析遗传因素对双生子吸烟、饮酒的影响。方法以青岛地区自愿参加本研究的年龄≥24周岁的双生子为对象,在卵型鉴定的基础上,采用Holzinger方法分析其吸烟、饮酒的遗传度。结果估计吸烟的遗传度为(66.5±5.53)%,重度吸烟的遗传度为(43.0±5.75)%。男性同卵双生子在吸烟行为上Kappa一致性检验K=0.453,P<0.001,异卵双生子K=0.307,P=0.005;饮酒的遗传度为(60.8±7.79)%,大量饮酒的遗传度为(22.2±9.80)%。男性同卵双生子在饮酒行为上Kappa一致性检验K=0.518,P<0.001,异卵双生子K=0.160,P=0.224。结论吸烟、饮酒受遗传因素影响较大;重度吸烟、大量饮酒受遗传因素影响较小。男性同卵双生子在吸烟、饮酒行为上呈现中度一致性,男性异卵双生子、女性双生子一致性差异无统计学意义。Objective To discuss the impact of inheritance on cigarette and alcohol consumption in twins. Methods Based on zygosity identification, the heritability of cigarette and alcohol consumption were studied in 503 pairs of twins, aged ≥ 24 years, who were voluntary to participate in this study. Holzinger analysis was employed to estimate the heritability of cigarette and alcohol consumption. Results The heritability estimated for cigarette smoking was （66.5± 5.53） %, heavy smoking was （43.0 ± 5.75） %, the Kappa consistency test was K = 0. 453 （P 〈 0. 001 ） in Monozygotic（MZ）, K = 0. 307 （ P = 0. 005） in Dizygotic（DZ） ;For alcohol consumption, the heritability was （60.8 ±7.79） %, amount of alcohol consumption was （22.2 ±9.80） %, the Kappa consistency was K = 0.518, P 〈 0. 001 in MZ, K = 0. 160, P = 0. 224 in DZ. Conclusion The influence of heritability is larger on alcohol and cigarette consumption. A significant genetic effect could not be observed for the amount of alcohol and heavy smoking. Kappa Test is moderate consistency on cigarette and alcohol consumption in male monozygotic, but not on female twins and male dizygotic.

关 键 词：成人双生子 遗传度 吸烟 饮酒 

分 类 号：R394-3[医药卫生—医学遗传学]