激光光动力学疗法治疗复发性鼻咽癌的研究——附191例分析  

Photodynamic Therapy for Recurrent Nasopharyngeal Carcinoma after Radiotherapy(An Analysis of 191 Cases)

作　　者：孙振权[1] 罗国仪[1] 

机构地区：[1]广州中山医科大学肿瘤医院

出　　处：《中国激光医学杂志》1996年第3期134-136,共3页Chinese Journal of Laser Medicine & Surgery

摘　　要：为提高复发性鼻咽癌的疗效，采用激光光动力学治疗（ＰＤＴ）１９１例复发性鼻咽癌和放射未控病例。方法是静脉滴注血卟啉衍生物（ＨｐＤ）５ｍｇ／ｋｇ后，于２４、４８和７２小时给予氩离子激光照射，输出为４８８．０～５１４．５ｎｍ多谱线，功率８００ｍＷ，通过石英导光纤维传导进入鼻咽腔。近期疗效是：完全效应率为５５．０％（１０５／１９１），明显效应率为３４．６％（６６／１９１），显著效应率为８９．５％（１７１／１９１）。随访１３０例，三年生存率４４．６％，五年生存率２５．４％。patients with recurrent and 71 with uncontrolled nasopharyngeal carcinoma after radiotherapy were treated by photodynamic therapy (PDT). Hematoporphyrin derivative (HpD) was administered i.v. in a dose of 5 mg/kg. The tumors were irradiated by argon laser via an optic fibre (488 0～514 5 nm,800 mW, 30 min for one side) at 24, 48 and 72 hours after HpD injection. The results were as follows: complete remission (CR) 105 cases (55 0%) and significant response (SR) 66 cases (34 6%). The over all improved response rate was 89 5%. Promising results of long term following up were obtained: among the 130 cases followed up for longer than 3 years, the 3 year survival rate was 44 6%(58/130),and 5 year survival rate was 25 4% (33/130). The indication, efficacy and drawbacks of PDT treatment for those types of nasopharyngeal carcinoma were discussed. It was proved that PDT is an effective auxillary therapy or a part of combined therapy for recurrent or uncontrolled nasopharyngeal carcinoma after radiotherapy.

关 键 词：鼻咽肿瘤 复发 PDT 激光疗法 

分 类 号：R739.630.5[医药卫生—肿瘤]